Flavor ingredient regulatory record
L-Alanyl-L-Glutamine
L-Alanyl-L-Glutamine is an amino acid in the sweet family, FEMA GRAS under FEMA number 4712 (CAS 39537-23-0). Its odor is sweet, umami, mild, savory.
- FEMA
- 4712
- CAS
- 39537-23-0
- JECFA
- 2121
- Formula
- C8H15N3O4
GRAS status: FEMA GRAS, publication 25. Recorded by FDA in the Substances Added to Food inventory under CAS 39537-23-0.
Structure
Identity
Also known as: L-Glutamine, L-alanyl-, L-Glutamine, N2-L-alanyl-, Glutamine, N2-L-alanyl-, Dipeptiven, Dipeptamin, L-Ala-L-Gln, 72: PN: US20070066537 PAGE: 17 claimed protein, GlutaMAX, Glutamax I, Alanyl-glutamine, 96: PN: WO2011146121 PAGE: 115 claimed sequence, Sustamine.
Can L-Alanyl-L-Glutamine be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
L-Alanyl-L-Glutamine is FEMA GRAS under FEMA number 4712. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for L-Alanyl-L-Glutamine. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2121, evaluated at the 76th meeting in 2012. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, umami, mild, savory.
Where it is used
L-Alanyl-L-Glutamine is used in beverage, nutritional supplements, sports drinks and food flavoring, typically as a sweet note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to L-Alanyl-L-Glutamine by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| L-Methionylglycine | 4692 | 78% | Not determined |
| Glutamyl-valyl-glycine | 4709 | 78% | Not determined |
| L-Glutamine | 3684 | 74% | In nature |
| l-Glutamic acid | 3285 | 65% | In nature |
| L-Arginine | 3819 | 65% | In nature |
More amino acids in this index
Glycine · L-Phenylalanine · L-Alanine · L-Threonine · Alanine · DL-Phenylalanine
L-Alanyl-L-Glutamine FAQ
Is L-Alanyl-L-Glutamine on the FEMA GRAS list?
It is. FEMA number 4712 covers L-Alanyl-L-Glutamine. It is also codified at 21 CFR 172.515.
What is the FEMA number for L-Alanyl-L-Glutamine?
The FEMA number for L-Alanyl-L-Glutamine is 4712 and its CAS registry number is 39537-23-0. FEMA files it in the sweet flavor category.
Is L-Alanyl-L-Glutamine approved in the EU?
No EU FL number is on file for L-Alanyl-L-Glutamine. It has a JECFA evaluation (JECFA 2121), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Has JECFA evaluated L-Alanyl-L-Glutamine?
Yes. JECFA number 2121, evaluated at the 76th meeting in 2012. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What is L-Alanyl-L-Glutamine used for?
L-Alanyl-L-Glutamine is described as sweet, umami, mild, savory. It shows up in beverage, nutritional supplements, sports drinks and food flavoring.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as L-ALANYL-L-GLUTAMINE under CAS 39537-23-0 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.