Flavor ingredient regulatory record
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide is an amide in the floral family, FEMA GRAS under FEMA number 4788 (CAS 1309389-73-8). Its odor is floral, sweet, herbal, green, slightly spicy.
- FEMA
- 4788
- CAS
- 1309389-73-8
- JECFA
- 2228
- EU FL
- 16.135
- Formula
- C22H17NO3
- EC
- 811-467-2
GRAS status: FEMA GRAS. Source: FEMA Flavor Ingredient Library.
Structure
![2D structure of (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide](/public/structures/fema-4788.svg)
Identity
Also known as: 2-Propenamide, 3-(1,3-benzodioxol-5-yl)-N,N-diphenyl-, (2E)-, (2E)-3-(1,3-Benzodioxol-5-yl)-N,N-diphenyl-2-propenamide, (E)-3-(Benzodioxol-5-yl)-N,N-diphenyl-2-propenamide, 2-propenamide, 3-(1,3-benzodioxol-5-yl)-n,n-diphenyl-, (2e)-, 3-benzo(1,3)dioxol-5-yl-n,n-diphenyl-2-propenamide, (e)-, 3-(1,3-benzodioxol-5-yl)-n,n-diphenylprop-2-enamide, (2e)-, us10584134, example 3-6, (2e)-3-(1,3-benzodioxol-5-yl)-n,n-diphenylacrylamide, (2e)-3-(2h-1,3-benzodioxol-5-yl)-n,n-diphenylprop-2-enamide.
Can (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide is FEMA GRAS under FEMA number 4788. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.135, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list. The entry carries use restrictions.
Use restrictions. In category 5 (other than 5.1, 5.3 and 5.4) - not more than 250 mg/kg In category 5.3 - not more than 500 mg/kg In category 5.4 - not more than 150 mg/kg
JECFA (WHO / FAO)
JECFA number 2228, evaluated at the 82nd meeting in 2016. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Floral, sweet, herbal, green, slightly spicy.
Where it is used
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide is used in fragrance, beverage, confection, flavoring and cosmetics, typically as a floral note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Piperine | 2909 | 77% | In nature |
| Anisyl phenylacetate | 3740 | 76% | In nature |
| Cinnamyl benzoate | 4703 | 76% | In nature |
| Cinnamyl cinnamate | 2298 | 76% | In nature |
| Phenethyl cinnamate | 2863 | 75% | In nature |
More amides in this index
N-(Heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide · Nonanoyl 4-hydroxy-3-methoxybenzylamide · N-(2-(Pyridin-2-yl)ethyl)-3-p-menthanecarboxamide · (2S,5R)-N-[4-(2-Amino-2-oxoethyl)phenyl]-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide · N-Ethyl-2,2-diisopropylbutanamide · Advantame
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide FAQ
Is (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide FEMA GRAS?
Yes. The FEMA Expert Panel lists (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide as GRAS under FEMA number 4788. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide?
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide is FEMA 4788, CAS 1309389-73-8. FEMA files it in the floral flavor category.
Is (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide on the EU Union List?
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide is on the EU Union List of flavouring substances as FL 16.135 (Annex I Part A) under Regulation 1334/2008. Its entry carries use restrictions, listed on this page.
Has JECFA evaluated (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide?
Yes. JECFA number 2228, evaluated at the 82nd meeting in 2016. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
How is (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide described, and where does it show up?
Flavorists describe (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide as floral, sweet, herbal, green, slightly spicy. It is used in fragrance, beverage, confection, flavoring and cosmetics.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
Check (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide in a formula
Screened against FEMA GRAS, 21 CFR and EU rules as you build. Free to start.
Sources and attribution. The FEMA number and GRAS status on this page name a conclusion reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States. FDA does not list this substance by FEMA number in its Substances Added to Food inventory. Its identity is attested by EU Union List of flavouring substances, matched on CAS 1309389-73-8.
FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.