Flavor ingredient regulatory record
(+/-)-Eriodictyol
(+/-)-Eriodictyol is a flavonoid in the fruity family, FEMA GRAS under FEMA number 4715 (CAS 4049-38-1). Its odor is citrus, sweet, floral, herbal.
- FEMA
- 4715
- CAS
- 4049-38-1
- JECFA
- 2172
GRAS status: FEMA GRAS, publication 25. Recorded by FDA in the Substances Added to Food inventory under CAS 4049-38-1.
Structure
Under review
The structure for (+/-)-Eriodictyol is still under identity review, so no drawing is shown until the record is confirmed.
Identity
Also known as: flavanone, 3',4',5,7-tetrahydroxy-, 4h-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, eriodictyol, (+-)-, (+-)-eriodictyol, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one, eriodictyol, (+/-)-, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-4-one, ( inverted exclamation marka)-eriodictyol, 5,7,3',4'-tetrahydroxyflavanone, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2h-1-benzopyran-4-one, eriodicytol.
Can (+/-)-Eriodictyol be labeled natural?
The process decides for (+/-)-Eriodictyol. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic (+/-)-Eriodictyol is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic (+/-)-Eriodictyol identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
(+/-)-Eriodictyol is FEMA GRAS under FEMA number 4715. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for (+/-)-Eriodictyol. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2172, evaluated at the 76th meeting in 2012. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Citrus, sweet, floral, herbal.
Taste: Sweet, slightly bitter, citrus.
Where it is used
(+/-)-Eriodictyol is used in beverage, confection, fruit flavors, nutraceuticals and cosmetics, typically as a fruity note.
More flavonoids in this index
(+/-)-Eriodictyol FAQ
Is (+/-)-Eriodictyol on the FEMA GRAS list?
It is. FEMA number 4715 covers (+/-)-Eriodictyol. The Code of Federal Regulations lists it at 21 CFR 172.515.
What is the FEMA number for (+/-)-Eriodictyol?
The FEMA number for (+/-)-Eriodictyol is 4715 and its CAS registry number is 4049-38-1. Its flavor category is fruity.
What is (+/-)-Eriodictyol used for?
(+/-)-Eriodictyol is described as citrus, sweet, floral, herbal. On the palate it is sweet, slightly bitter, citrus. It shows up in beverage, confection, fruit flavors, nutraceuticals and cosmetics.
What did JECFA conclude about (+/-)-Eriodictyol?
JECFA evaluated (+/-)-Eriodictyol at the 76th meeting in 2012 under JECFA number 2172. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Is (+/-)-Eriodictyol approved in the EU?
No EU FL number is on file for (+/-)-Eriodictyol. It has a JECFA evaluation (JECFA 2172), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Is (+/-)-Eriodictyol natural or artificial?
Nature makes (+/-)-Eriodictyol, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial (+/-)-Eriodictyol, same molecule. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as (+/-)-ERIODICTYOL under CAS 4049-38-1 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.