Flavor ingredient regulatory record
Neohesperidin dihydrochalcone
Neohesperidin dihydrochalcone is a flavonoid in the citrus family, FEMA GRAS under FEMA number 3811 (CAS 20702-77-6). Its odor is sweet, citrus, orange, floral, herbal.
- FEMA
- 3811
- CAS
- 20702-77-6
- EU FL
- 16.061
- Formula
- C28H36O15
- EC
- 243-978-6
GRAS status: FEMA GRAS, publication 17, 23. Recorded by FDA in the Substances Added to Food inventory under CAS 20702-77-6.
Structure
Identity
Also known as: 1-Propanone, 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-, Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-α-L-mannopyranosyl)-, β-D-, Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-α-L-rhamnopyranosyl-, 1-[4-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-1-propanone, Neohesperidin DHC, Neohesperidine dihydrochalcone, NHDC, Neohesperidin DC, Citrosa, nhdc, neohesperidin dc, neohesperidin dhc.
Can Neohesperidin dihydrochalcone be labeled natural?
The process decides for neohesperidin dihydrochalcone. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic neohesperidin dihydrochalcone is artificial. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Neohesperidin dihydrochalcone is FEMA GRAS under FEMA number 3811. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.061, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list. The entry carries use restrictions.
Use restrictions. Restrictions for use as a flavouring substance: In categories 1, 3, 4.2, 6, 8, 9, 10, 12 and 14 - not more than 3 mg/kg In categories 2, 5 and 7 - not more than 4 mg/kg In category 15 - not more than 5 mg/kg
JECFA (WHO / FAO)
Neohesperidin dihydrochalcone has not been evaluated by JECFA as a flavouring agent, or no evaluation is on file.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, citrus, orange, floral, herbal.
Taste: Sweet, bitter, citrus.
Where it is used
Neohesperidin dihydrochalcone is used in beverage, confection, flavoring and dietary supplements, typically as a citrus note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Neohesperidin dihydrochalcone by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Naringin dihydrochalcone | 4495 | 99% | Not determined |
| Naringen Extract | 2769 | 96% | In nature |
| Trilobatin | 4674 | 94% | In nature |
| Myricitrin | 4491 | 91% | In nature |
| Rebaudioside A | 4601 | 89% | In nature |
More flavonoids in this index
Neohesperidin dihydrochalcone FAQ
Does neohesperidin dihydrochalcone have FEMA GRAS status?
Neohesperidin dihydrochalcone holds FEMA GRAS status under FEMA number 3811. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite neohesperidin dihydrochalcone by FEMA or CAS number?
Cite neohesperidin dihydrochalcone as FEMA 3811 or CAS 20702-77-6; both point to the same entry. Its flavor category is citrus.
What does neohesperidin dihydrochalcone smell and taste like, and where is it used?
The odor of neohesperidin dihydrochalcone is sweet, citrus, orange, floral, herbal. On the palate it is sweet, bitter, citrus. Typical uses are beverage, confection, flavoring and dietary supplements.
Can neohesperidin dihydrochalcone be used in the EU and UK?
Yes. FL 16.061 is the Union List entry for neohesperidin dihydrochalcone, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list. Its entry carries use restrictions, listed on this page.
Can neohesperidin dihydrochalcone be labeled a natural flavor?
Nature makes neohesperidin dihydrochalcone, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial neohesperidin dihydrochalcone, same molecule. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic neohesperidin dihydrochalcone identical-to-natural.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as NEOHESPERIDIN DIHYDROCHALCONE under CAS 20702-77-6 and carries its FEMA number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.