Flavor ingredient regulatory record
Myricitrin
Myricitrin is a glycoside in the fruity family, FEMA GRAS under FEMA number 4491 (CAS 17912-87-7). Its odor is sweet, fruity, floral, herbal.
- FEMA
- 4491
- CAS
- 17912-87-7
- JECFA
- 2207
- Formula
- C21H20O12
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 17912-87-7.
Structure
Identity
Also known as: 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-, 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one, Myricetin 3-rhamnoside, Myricitroside, Myricetin 3-O-α-L-rhamnoside, Myricitrine, 3,3′,4′,5,5′,7-Hexahydroxyflavone, 3-rhamnoside, Myricetin 3-O-α-L-rhamnopyranoside, Myricetin 3-O-rhamnoside, Myricetin 3-O-α-rhamnopyranoside, NSC 19803, Myricetin-3-O-α-rhamnoside.
Can Myricitrin be labeled natural?
The process decides for myricitrin. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic myricitrin is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Myricitrin is FEMA GRAS under FEMA number 4491. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Myricitrin. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2207, evaluated at the 79th meeting in 2014. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, floral, herbal.
Taste: Sweet, mildly bitter, fruity.
Where it is used
Myricitrin is used in beverage, confection, fruit flavors and nutraceuticals, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Myricitrin by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Trilobatin | 4674 | 92% | In nature |
| Naringin dihydrochalcone | 4495 | 92% | Not determined |
| Neohesperidin dihydrochalcone | 3811 | 91% | In nature |
| Ethyl vanillin beta-D-glucopyranoside | 3801 | 79% | In nature |
| Rebaudioside A | 4601 | 76% | In nature |
More glycosides in this index
Rebaudioside C · Ethyl vanillin beta-D-glucopyranoside · Rebaudioside A
Myricitrin FAQ
Is myricitrin FEMA GRAS?
Yes. The FEMA Expert Panel lists myricitrin as GRAS under FEMA number 4491. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for myricitrin?
Myricitrin is FEMA 4491, CAS 17912-87-7. Its flavor category is fruity.
How is myricitrin described, and where does it show up?
Flavorists describe myricitrin as sweet, fruity, floral, herbal. On the palate it is sweet, mildly bitter, fruity. It is used in beverage, confection, fruit flavors and nutraceuticals.
What did JECFA conclude about myricitrin?
JECFA evaluated myricitrin at the 79th meeting in 2014 under JECFA number 2207. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Is myricitrin approved in the EU?
No EU FL number is on file for myricitrin. It has a JECFA evaluation (JECFA 2207), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Does myricitrin count as natural in the US and the EU?
Nature makes myricitrin, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial myricitrin, same molecule. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as MYRICITRIN under CAS 17912-87-7 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.