Flavor ingredient regulatory record
Ethyl vanillin beta-D-glucopyranoside
Ethyl vanillin beta-D-glucopyranoside is a glycoside in the vanilla family, FEMA GRAS under FEMA number 3801 (CAS 122397-96-0). Its odor is sweet, creamy, vanilla, floral, caramel.
- FEMA
- 3801
- CAS
- 122397-96-0
- JECFA
- 892
- EU FL
- 16.075
- Formula
- C15H20O8
GRAS status: FEMA GRAS, publication 17. Recorded by FDA in the Substances Added to Food inventory under CAS 122397-96-0.
Structure
Identity
Also known as: Benzaldehyde, 3-ethoxy-4-(β-D-glucopyranosyloxy)-, 3-Ethoxy-4-(β-D-glucopyranosyloxy)benzaldehyde, Ethyl vanillin glucoside, 2-Ethoxy-4-formylphenyl β-D-glucopyranoside, Ethyl vanillin β-D-glucopyranoside, (4-Formyl-2-ethoxyphenyl) β-d-glucopyranoside, ethyl vanillin glucoside, glucoethylvanillin, 3-ethoxy-4-(beta-d-glucopyranosyloxy)benzaldehyde, benzaldehyde, 3-ethoxy-4-(beta-d-glucopyranosyloxy)-, ethyl vanillin .beta.-d-glucopyranoside, ethyl vanillin .beta.-d-glucopyranoside [fhfi].
Can Ethyl vanillin beta-D-glucopyranoside be labeled natural?
Nature makes Ethyl vanillin beta-D-glucopyranoside, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial Ethyl vanillin beta-D-glucopyranoside, same molecule. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic Ethyl vanillin beta-D-glucopyranoside identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Ethyl vanillin beta-D-glucopyranoside is FEMA GRAS under FEMA number 3801. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.075, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 892, evaluated at the 57th meeting in 2001. No safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, creamy, vanilla, floral, caramel.
Taste: Sweet, smooth, vanilla.
Where it is used
Ethyl vanillin beta-D-glucopyranoside is used in baked goods, confectionery, beverages, dairy and flavoring, typically as a vanilla note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Ethyl vanillin beta-D-glucopyranoside by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Naringin dihydrochalcone | 4495 | 83% | Not determined |
| Neohesperidin dihydrochalcone | 3811 | 81% | In nature |
| Trilobatin | 4674 | 80% | In nature |
| Myricitrin | 4491 | 79% | In nature |
| Rebaudioside A | 4601 | 74% | In nature |
More glycosides in this index
Ethyl vanillin beta-D-glucopyranoside FAQ
Is Ethyl vanillin beta-D-glucopyranoside FEMA GRAS?
Yes. The FEMA Expert Panel lists Ethyl vanillin beta-D-glucopyranoside as GRAS under FEMA number 3801. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for Ethyl vanillin beta-D-glucopyranoside?
Ethyl vanillin beta-D-glucopyranoside is FEMA 3801, CAS 122397-96-0. Its flavor category is vanilla.
How is Ethyl vanillin beta-D-glucopyranoside described, and where does it show up?
Flavorists describe Ethyl vanillin beta-D-glucopyranoside as sweet, creamy, vanilla, floral, caramel. On the palate it is sweet, smooth, vanilla. It is used in baked goods, confectionery, beverages, dairy and flavoring.
What did JECFA conclude about Ethyl vanillin beta-D-glucopyranoside?
JECFA evaluated Ethyl vanillin beta-D-glucopyranoside at the 57th meeting in 2001 under JECFA number 892. The panel concluded: No safety concern at current levels of intake.
Is Ethyl vanillin beta-D-glucopyranoside on the EU Union List?
Yes. FL 16.075 is the Union List entry for Ethyl vanillin beta-D-glucopyranoside, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Does Ethyl vanillin beta-D-glucopyranoside count as natural in the US and the EU?
The process decides for Ethyl vanillin beta-D-glucopyranoside. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic Ethyl vanillin beta-D-glucopyranoside is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic Ethyl vanillin beta-D-glucopyranoside identical-to-natural.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ETHYL VANILLIN BETA-D-GLUCOPYRANOSIDE under CAS 122397-96-0 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.