Flavor ingredient regulatory record

Rebaudioside C

Rebaudioside C is a glycoside in the sweet family, FEMA GRAS under FEMA number 4720 (CAS 63550-99-2). Its odor is sweet, fruity, herbal, green.

FEMA: 4720
CAS: 63550-99-2
Formula: C44H70O22

GRAS status: FEMA GRAS, publication 25. Recorded by FDA in the Substances Added to Food inventory under CAS 63550-99-2.

Structure

Identity

IUPAC name [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylate

CAS number 63550-99-2

FEMA number 4720

Molecular formula C44H70O22

Molecular weight 951.02 g/mol

SMILES C=C1C[C@@]23CC[C@H]4[C@@](C)(CCC[C@@]4(C)C(=O)O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H]2CC[C@]1(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C3

InChIKey QSRAJVGDWKFOGU-WBXIDTKBSA-N

PubChem CID 60208888

FDA UNII FE0M8Z5L2E

EPA DTXSID DTXSID301019859

Chemical class Glycoside

Also known as: Kaur-16-en-18-oic acid, 13-[(O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl)oxy]-, β-D-glucopyranosyl ester, (4α)-, Dulcoside B, RBDS-C, rebaudiosidec, dulcoside b, (-)-rebaudioside c, rebaudioside-c, rebaudioside c?, rebc, rebaudioside c [mi], rebaudioside c, (-)-, hy-n0467.

Can Rebaudioside C be labeled natural?

Rebaudioside C occurs in nature, so the label depends on the route: Rebaudioside C won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized Rebaudioside C is artificial. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.

United States: Natural or artificial, by process
European Union and UK: Natural only from natural material
Mercosur and Mexico: Natural or identical-to-natural

How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.

Regulatory status, with citations

United States

Rebaudioside C is FEMA GRAS under FEMA number 4720. It is cited in the Code of Federal Regulations at 21 CFR 172.515.

21 CFR 172.515

European Union and United Kingdom

No EU FL number is on file for Rebaudioside C. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.

JECFA (WHO / FAO)

Rebaudioside C has not been evaluated by JECFA as a flavouring agent, or no evaluation is on file.

Other US flags

Not on the California Proposition 65 list.

Odor and taste

Odor: Sweet, fruity, herbal, green.

Taste: Sweet, refreshing, mild.

Where it is used

Rebaudioside C is used in beverage, confection, sweeteners and dairy, typically as a sweet note.

More glycosides in this index

Rebaudioside A · Myricitrin · Ethyl vanillin beta-D-glucopyranoside

Rebaudioside C FAQ

Does Rebaudioside C have FEMA GRAS status?

Rebaudioside C holds FEMA GRAS status under FEMA number 4720. It is also codified at 21 CFR 172.515.

How do I cite Rebaudioside C by FEMA or CAS number?

Cite Rebaudioside C as FEMA 4720 or CAS 63550-99-2; both point to the same entry. FEMA files it in the sweet flavor category.

Can Rebaudioside C be labeled a natural flavor?

Since Rebaudioside C is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when Rebaudioside C is synthesized. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.

What does Rebaudioside C smell and taste like, and where is it used?

The odor of Rebaudioside C is sweet, fruity, herbal, green. On the palate it is sweet, refreshing, mild. Typical uses are beverage, confection, sweeteners and dairy.

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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as REBAUDIOSIDE C under CAS 63550-99-2 and carries its FEMA number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.

A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.

Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.

About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.