Flavor ingredient regulatory record
Naringin dihydrochalcone
Naringin dihydrochalcone is a flavonoid in the fruity family, FEMA GRAS under FEMA number 4495 (CAS 18916-17-1). Its odor is sweet, citrus, grapefruit, herbal.
- FEMA
- 4495
- CAS
- 18916-17-1
- JECFA
- 2208
- EU FL
- 16.110
- Formula
- C27H34O14
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 18916-17-1.
Structure
Identity
Also known as: 1-Propanone, 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-, Glucopyranoside, 3,5-dihydroxy-4-(p-hydroxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-α-L-mannopyranosyl)-, β-D-, Phloretin, 4′-(2-O-α-L-rhamno-β-D-glucopyranoside), 1-[4-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone, phloretin, 4'-(2-o-alpha-l-rhamno-beta-d-glucopyranoside), glucopyranoside, 3,5-dihydroxy-4-(p-hydroxyhydrocinnamoyl)phenyl 2-o-(6-deoxy-alpha-l-mannopyranosyl)-, beta-d-, naringin dc, naringindihydrochalcone, naringin-dihydrochalcone, hy-n0119r, hy-n0119, naringin dihydrochalcone (standard).
Can Naringin dihydrochalcone be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
Naringin dihydrochalcone is FEMA GRAS under FEMA number 4495. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.110, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 2208, evaluated at the 79th meeting in 2014. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list. Listed on the EPA TSCA inventory.
Odor and taste
Odor: Sweet, citrus, grapefruit, herbal.
Taste: Bitter, sweet, citrus.
Where it is used
Naringin dihydrochalcone is used in beverage, confection, dietary supplements and flavoring agents, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Naringin dihydrochalcone by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Neohesperidin dihydrochalcone | 3811 | 99% | In nature |
| Naringen Extract | 2769 | 97% | In nature |
| Trilobatin | 4674 | 96% | In nature |
| Myricitrin | 4491 | 92% | In nature |
| Rebaudioside A | 4601 | 88% | In nature |
More flavonoids in this index
Naringin dihydrochalcone FAQ
Does naringin dihydrochalcone have FEMA GRAS status?
Naringin dihydrochalcone holds FEMA GRAS status under FEMA number 4495. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite naringin dihydrochalcone by FEMA or CAS number?
Cite naringin dihydrochalcone as FEMA 4495 or CAS 18916-17-1; both point to the same entry. Its flavor category is fruity.
What does naringin dihydrochalcone smell and taste like, and where is it used?
The odor of naringin dihydrochalcone is sweet, citrus, grapefruit, herbal. On the palate it is bitter, sweet, citrus. Typical uses are beverage, confection, dietary supplements and flavoring agents.
What did JECFA conclude about naringin dihydrochalcone?
JECFA evaluated naringin dihydrochalcone at the 79th meeting in 2014 under JECFA number 2208. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Can naringin dihydrochalcone be used in the EU and UK?
Yes. FL 16.110 is the Union List entry for naringin dihydrochalcone, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as NARINGIN DIHYDROCHALCONE under CAS 18916-17-1 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.