Flavor ingredient regulatory record
Ethyl 5-acetoxyoctanoate
Ethyl 5-acetoxyoctanoate is an ester in the fruity family, FEMA GRAS under FEMA number 4443 (CAS 35234-25-4). Its odor is sweet, fruity, tropical, peach, apple.
- FEMA
- 4443
- CAS
- 35234-25-4
- JECFA
- 1959
- Formula
- C12H22O4
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 35234-25-4.
Structure
Identity
Also known as: Octanoic acid, 5-(acetyloxy)-, ethyl ester, δ-Acetoxyoctanoic acid, ethyl ester, ethyl 5-(acetyloxy)octanoate, octanoic acid, 5-(acetyloxy)-, ethyl ester, .delta.-acetoxyoctanoic acid, ethyl ester, ethyl 5-acetyloxyoctanoate, (+-)-ethyl 5-acetoxyoctanoate, ethyl 5-acetoxyoctanoate, (+-)-, delta-acetoxyoctanoic acid, ethyl ester, (+/-)-ethyl 5-acetoxyoctanoate, ethyl 5-acetoxyoctanoate, (+/-)-.
Can Ethyl 5-acetoxyoctanoate be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
Ethyl 5-acetoxyoctanoate is FEMA GRAS under FEMA number 4443. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Ethyl 5-acetoxyoctanoate. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 1959, evaluated at the 64th meeting in 2005. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, tropical, peach, apple.
Where it is used
Ethyl 5-acetoxyoctanoate is used in beverage, confection, fruit flavors, ice cream and baked goods, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Ethyl 5-acetoxyoctanoate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Ethyl 2-acetyloctanoate | 4459 | 73% | Not determined |
| 3-Octyl butyrate | 4402 | 72% | Not determined |
| Hydroxycitronellal diethyl acetal | 2584 | 68% | In nature |
| Dihydrogalangal acetate | 4555 | 68% | In nature |
More esters in this index
Hexyl acetate · 1-Isobutoxy-1-ethoxyethane · Trilobatin · Isoamyl cinnamate · Methyl (E)-2-(Z)-4-decadienoate · Isobutyl cinnamate
Ethyl 5-acetoxyoctanoate FAQ
Is ethyl 5-acetoxyoctanoate FEMA GRAS?
Yes. The FEMA Expert Panel lists ethyl 5-acetoxyoctanoate as GRAS under FEMA number 4443. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for ethyl 5-acetoxyoctanoate?
Ethyl 5-acetoxyoctanoate is FEMA 4443, CAS 35234-25-4. Its flavor category is fruity.
How is ethyl 5-acetoxyoctanoate described, and where does it show up?
Flavorists describe ethyl 5-acetoxyoctanoate as sweet, fruity, tropical, peach, apple. It is used in beverage, confection, fruit flavors, ice cream and baked goods.
What did JECFA conclude about ethyl 5-acetoxyoctanoate?
JECFA evaluated ethyl 5-acetoxyoctanoate at the 64th meeting in 2005 under JECFA number 1959. The panel concluded: no safety concern at current levels of intake.
Is ethyl 5-acetoxyoctanoate approved in the EU?
No EU FL number is on file for ethyl 5-acetoxyoctanoate. It has a JECFA evaluation (JECFA 1959), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ETHYL 5-ACETOXYOCTANOATE under CAS 35234-25-4 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.