Flavor ingredient regulatory record

Tetrahydrofurfuryl cinnamate

Tetrahydrofurfuryl cinnamate is an ester in the fruity family, FEMA GRAS under FEMA number 3320 (CAS 65505-25-1). Its odor is sweet, fruity, floral, cinnamon, warm.

FEMA
3320
CAS
65505-25-1
JECFA
1447
EU FL
13.060
Formula
C14H16O3
EC
265-799-2

GRAS status: FEMA GRAS, publication 5. Recorded by FDA in the Substances Added to Food inventory under CAS 65505-25-1.

Structure

2D structure of Tetrahydrofurfuryl cinnamate
Structure of Tetrahydrofurfuryl cinnamate, C14H16O3. Drawn from the canonical SMILES.

Identity

IUPAC name oxolan-2-ylmethyl (E)-3-phenylprop-2-enoate
CAS number 65505-25-1
FEMA number 3320
Molecular formula C14H16O3
Molecular weight 232.28 g/mol
SMILES O=C(/C=C/c1ccccc1)OCC1CCCO1
InChIKey QCMSQCLNALBZOD-CMDGGOBGSA-N
PubChem CID 6232217
EC number 265-799-2
FDA UNII 5HQB67K00K
EPA DTXSID DTXSID40867159
Chemical class Ester
Boiling point 391 °C
Flash point 185 °C

Also known as: 2-Propenoic acid, 3-phenyl-, (tetrahydro-2-furanyl)methyl ester, (Tetrahydro-2-furanyl)methyl 3-phenyl-2-propenoate, oxolan-2-ylmethyl (e)-3-phenylprop-2-enoate, tetrahydro-2-furylmethyl cinnamate, tetrahydrofurfuryl 3-phenylpropenoate, tetrahydro-2-furylmethyl 3-phenylpropenoate, 2-propenoic acid, 3-phenyl-, (tetrahydro-2-furanyl)methyl ester, tetrahydrofurfuryl cinnamate [fhfi], oxolan-2-ylmethyl (2e)-3-phenylprop-2-enoate, (+-)-tetrahydrofurfuryl cinnamate, (tetrahydro-2-furanyl)methyl 3-phenyl-2-propenoate, 2-propenoic acid,3-phenyl-, (tetrahydro-2-furanyl)methyl ester.

Can Tetrahydrofurfuryl cinnamate be labeled natural?

Tetrahydrofurfuryl cinnamate occurs in nature, so the label depends on the route: tetrahydrofurfuryl cinnamate won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized tetrahydrofurfuryl cinnamate is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic tetrahydrofurfuryl cinnamate identical-to-natural.

United States
Natural or artificial, by process
European Union and UK
Natural only from natural material
Mercosur and Mexico
Natural or identical-to-natural

How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.

Regulatory status, with citations

United States

Tetrahydrofurfuryl cinnamate is FEMA GRAS under FEMA number 3320. It is cited in the Code of Federal Regulations at 21 CFR 172.515.

21 CFR 172.515

European Union and United Kingdom

Listed on the Union List of flavouring substances as FL 13.060, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.

JECFA (WHO / FAO)

JECFA number 1447, evaluated at the 63rd meeting in 2004. No safety concern at current levels of intake when used as a flavouring agent.

JECFA monograph

Other US flags

Not on the California Proposition 65 list.

Odor and taste

Odor: Sweet, fruity, floral, cinnamon, warm.

Where it is used

Tetrahydrofurfuryl cinnamate is used in beverage, confection, baked goods, flavoring and desserts, typically as a fruity note.

Structurally similar flavor ingredients

Flavor ingredients with a GRAS determination closest to Tetrahydrofurfuryl cinnamate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.

MaterialFEMASimilarityOccurrence
Cyclohexyl cinnamate235284%In nature
Phenethyl cinnamate286380%In nature
Isoamyl cinnamate206380%In nature
Cinnamyl cinnamate229879%In nature
Benzyl cinnamate214278%In nature

More esters in this index

Triethyl citrate · Guaiacol isobutyrate · Methyl anisate · Phenethyl cinnamate · Ethyl sorbate · cis-3-Hexenyl anthranilate

Tetrahydrofurfuryl cinnamate FAQ

Is tetrahydrofurfuryl cinnamate on the FEMA GRAS list?

It is. FEMA number 3320 covers tetrahydrofurfuryl cinnamate. It is also codified at 21 CFR 172.515.

What is the FEMA number for tetrahydrofurfuryl cinnamate?

The FEMA number for tetrahydrofurfuryl cinnamate is 3320 and its CAS registry number is 65505-25-1. FEMA files it in the fruity flavor category.

Is tetrahydrofurfuryl cinnamate natural or artificial?

Since tetrahydrofurfuryl cinnamate is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when tetrahydrofurfuryl cinnamate is synthesized. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic tetrahydrofurfuryl cinnamate identical-to-natural.

Is tetrahydrofurfuryl cinnamate approved in the EU?

Tetrahydrofurfuryl cinnamate is on the EU Union List of flavouring substances as FL 13.060 (Annex I Part A) under Regulation 1334/2008.

Has JECFA evaluated tetrahydrofurfuryl cinnamate?

Yes. JECFA number 1447, evaluated at the 63rd meeting in 2004. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.

What is tetrahydrofurfuryl cinnamate used for?

Tetrahydrofurfuryl cinnamate is described as sweet, fruity, floral, cinnamon, warm. It shows up in beverage, confection, baked goods, flavoring and desserts.

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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as TETRAHYDROFURFURYL CINNAMATE under CAS 65505-25-1 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.

A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.

Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.

About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.