Flavor ingredient regulatory record

Cyclohexyl cinnamate

Cyclohexyl cinnamate is an ester in the fruity family, FEMA GRAS under FEMA number 2352 (CAS 7779-17-1).

FEMA
2352
CAS
7779-17-1
JECFA
667
EU FL
09.744
Formula
C15H18O2
EC
231-921-8

GRAS status: FEMA GRAS, publication 3. Recorded by FDA in the Substances Added to Food inventory under CAS 7779-17-1.

Structure

2D structure of Cyclohexyl cinnamate
Structure of Cyclohexyl cinnamate, C15H18O2. Drawn from the canonical SMILES.

Identity

IUPAC name cyclohexyl (E)-3-phenylprop-2-enoate
CAS number 7779-17-1
FEMA number 2352
Molecular formula C15H18O2
Molecular weight 230.31 g/mol
SMILES O=C(/C=C/c1ccccc1)OC1CCCCC1
InChIKey GCFAUZGWPDYAJN-VAWYXSNFSA-N
PubChem CID 5357153
EC number 231-921-8
Chemical class Ester
Boiling point 195 °C

Also known as: 2-Propenoic acid, 3-phenyl-, cyclohexyl ester, Cinnamic acid, cyclohexyl ester, NSC 71968, cinnamic acid, cyclohexyl ester, cyclohexyl trans-cinnamate, 2-propenoic acid, 3-phenyl-, cyclohexyl ester, cyclohexyl 3-phenylpropenoate, cyclohexyl 3-phenyl-2-propenoate, cyclohexyl cinnamate [fifh], ai3-02424, 2-propenoic acid, 3-phenyl-, cyclohexyl ester, (e)-, 2-propenoic acid, 3-phenyl-, cyclohexyl ester, (2e)-.

Can Cyclohexyl cinnamate be labeled natural?

Cyclohexyl cinnamate occurs in nature, so the label depends on the route: cyclohexyl cinnamate won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized cyclohexyl cinnamate is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.

United States
Natural or artificial, by process
European Union and UK
Natural only from natural material
Mercosur and Mexico
Natural or identical-to-natural

How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.

Regulatory status, with citations

United States

Cyclohexyl cinnamate is FEMA GRAS under FEMA number 2352. It is cited in the Code of Federal Regulations at 21 CFR 172.515.

21 CFR 172.515

European Union and United Kingdom

Listed on the Union List of flavouring substances as FL 09.744, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.

JECFA (WHO / FAO)

JECFA number 667, evaluated at the 55th meeting in 2000. no safety concern at current levels of intake.

JECFA monograph

Other US flags

Not on the California Proposition 65 list.

Odor and taste

Taste: Sweet, fruity, warm.

Where it is used

Cyclohexyl cinnamate is used in beverage, confection, baked goods, flavoring and perfume, typically as a fruity note.

Structurally similar flavor ingredients

Flavor ingredients with a GRAS determination closest to Cyclohexyl cinnamate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.

MaterialFEMASimilarityOccurrence
Cinnamyl cinnamate229886%In nature
Isoamyl cinnamate206384%In nature
Benzyl cinnamate214284%In nature
Cinnamyl benzoate470384%In nature
Tetrahydrofurfuryl cinnamate332084%In nature

More esters in this index

n-Amyl octanoate · Rum ether · Ethyl sorbate · Methyl anthranilate · Octyl octanoate · Butyl stearate

Cyclohexyl cinnamate FAQ

Is cyclohexyl cinnamate FEMA GRAS?

Yes. The FEMA Expert Panel lists cyclohexyl cinnamate as GRAS under FEMA number 2352. It is also codified at 21 CFR 172.515.

What are the FEMA and CAS numbers for cyclohexyl cinnamate?

Cyclohexyl cinnamate is FEMA 2352, CAS 7779-17-1. FEMA files it in the fruity flavor category.

Does cyclohexyl cinnamate count as natural in the US and the EU?

Since cyclohexyl cinnamate is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when cyclohexyl cinnamate is synthesized. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.

Is cyclohexyl cinnamate on the EU Union List?

Cyclohexyl cinnamate is on the EU Union List of flavouring substances as FL 09.744 (Annex I Part A) under Regulation 1334/2008.

Has JECFA evaluated cyclohexyl cinnamate?

Yes. JECFA number 667, evaluated at the 55th meeting in 2000. Conclusion: no safety concern at current levels of intake.

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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as CYCLOHEXYL CINNAMATE under CAS 7779-17-1 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.

A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.

Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.

About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.