Flavor ingredient regulatory record
Hexan-3-ol
Hexan-3-ol is an alcohol in the fruity family, FEMA GRAS under FEMA number 3351 (CAS 623-37-0). Its odor is sweet, fruity, apple, floral, green.
- FEMA
- 3351
- CAS
- 623-37-0
- JECFA
- 282
- EU FL
- 02.089
- Formula
- C6H14O
GRAS status: FEMA GRAS, publication 6. Recorded by FDA in the Substances Added to Food inventory under CAS 623-37-0.
Structure
Identity
Also known as: 3-Hexanol, 3-Hexyl alcohol, (±)-3-Hexanol, DL-3-Hexanol, NSC 60708, 1-Ethylbutanol, 1-Ethyl-1-butanol, 3-hexanol, ethyl propyl carbinol, ethylpropylcarbinol, 3-hexanol (natural), hexanol-(3).
Can Hexan-3-ol be labeled natural?
The process decides for hexan-3-ol. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic hexan-3-ol is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Hexan-3-ol is FEMA GRAS under FEMA number 3351. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 02.089, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (JECFA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 282, evaluated at the 51st meeting in 1998. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Hexan-3-ol appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 623-37-0, where EPA names it 3-Hexanol.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, apple, floral, green.
Where it is used
Hexan-3-ol is used in beverage, confection, fruit flavors, bakery and dairy, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Hexan-3-ol by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 3-Hexanone | 3290 | 94% | In nature |
| Amyl alcohol | 2056 | 92% | In nature |
| 3-Methyl-1-pentanol | 3762 | 88% | In nature |
| 2-Pentanol | 3316 | 87% | In nature |
| 3-Heptanol | 3547 | 86% | In nature |
More alcohols in this index
3-Methyl-1-pentanol · 2,4-Nonadien-1-ol · alpha-Amylcinnamyl alcohol · (Z,Z)-3,6-Nonadien-1-ol · 1-Phenyl-3-methyl-3-pentanol · (+/-)-1-Cyclohexylethanol
Hexan-3-ol FAQ
Is hexan-3-ol FEMA GRAS?
Yes. The FEMA Expert Panel lists hexan-3-ol as GRAS under FEMA number 3351. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for hexan-3-ol?
Hexan-3-ol is FEMA 3351, CAS 623-37-0. Its flavor category is fruity.
How is hexan-3-ol described, and where does it show up?
Flavorists describe hexan-3-ol as sweet, fruity, apple, floral, green. It is used in beverage, confection, fruit flavors, bakery and dairy.
What did JECFA conclude about hexan-3-ol?
JECFA evaluated hexan-3-ol at the 51st meeting in 1998 under JECFA number 282. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Is hexan-3-ol on the EU Union List?
Yes. FL 02.089 is the Union List entry for hexan-3-ol, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Does hexan-3-ol count as natural in the US and the EU?
Nature makes hexan-3-ol, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial hexan-3-ol, same molecule. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 3-HEXANOL under CAS 623-37-0 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.