Flavor ingredient regulatory record
3-Hexanone
3-Hexanone is a ketone in the fruity family, FEMA GRAS under FEMA number 3290 (CAS 589-38-8). Its odor is sweet, fruity, green apple, pear, solvent-like.
- FEMA
- 3290
- CAS
- 589-38-8
- JECFA
- 281
- EU FL
- 07.096
- Formula
- C6H12O
- EC
- 209-645-4
GRAS status: FEMA GRAS, publication 5. Recorded by FDA in the Substances Added to Food inventory under CAS 589-38-8.
Structure
Identity
Also known as: Ethyl propyl ketone, 3-Oxohexane, hexan-3-one, ethyl propyl ketone, 3-oxohexane, aethylpropylketon, ethyl n-propyl ketone, 3-hexanone, analytical standard, 3-hexanone (natural), aethylpropylketon [german], pentanone, methyl-, hexanone-(3).
Can 3-Hexanone be labeled natural?
Since 3-Hexanone is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when 3-Hexanone is synthesized. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
3-Hexanone is FEMA GRAS under FEMA number 3290. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 07.096, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (JECFA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 281, evaluated at the 51st meeting in 1998. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. 3-Hexanone appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 589-38-8, where EPA names it 3-Hexanone.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, green apple, pear, solvent-like.
Where it is used
3-Hexanone is used in beverage, confection, fruit flavors, bakery and snack foods, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 3-Hexanone by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 4-Hexen-3-one | 3352 | 95% | In nature |
| Hexan-3-ol | 3351 | 94% | In nature |
| 2,3-Hexanedione | 2558 | 93% | In nature |
| Methyl thiobutyrate | 3310 | 92% | In nature |
| Propyl acetate | 2925 | 87% | In nature |
More ketones in this index
1-Penten-3-one · 2,3-Octanedione · 1-(3-Hydroxy-5-methyl-2-thienyl)ethanone · 1-Ethyl-2-acetylpyrrole · 4-Acetyl-2-isopropenylpyridine · 2,3-Hexanedione
3-Hexanone FAQ
Is 3-Hexanone on the FEMA GRAS list?
It is. FEMA number 3290 covers 3-Hexanone. It is also codified at 21 CFR 172.515.
What is the FEMA number for 3-Hexanone?
The FEMA number for 3-Hexanone is 3290 and its CAS registry number is 589-38-8. FEMA files it in the fruity flavor category.
Is 3-Hexanone natural or artificial?
3-Hexanone occurs in nature, so the label depends on the route: 3-Hexanone won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized 3-Hexanone is artificial. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
Is 3-Hexanone approved in the EU?
3-Hexanone is on the EU Union List of flavouring substances as FL 07.096 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated 3-Hexanone?
Yes. JECFA number 281, evaluated at the 51st meeting in 1998. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What is 3-Hexanone used for?
3-Hexanone is described as sweet, fruity, green apple, pear, solvent-like. It shows up in beverage, confection, fruit flavors, bakery and snack foods.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 3-HEXANONE under CAS 589-38-8 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.