Flavor ingredient regulatory record
Isoeugenyl ethyl ether
Isoeugenyl ethyl ether is an ether in the fruity family, FEMA GRAS under FEMA number 2472 (CAS 7784-67-0). Its odor is sweet, floral, fruity, herbal.
- FEMA
- 2472
- CAS
- 7784-67-0
- JECFA
- 1267
- EU FL
- 04.017
- Formula
- C12H16O2
- EC
- 232-072-6
GRAS status: FEMA GRAS, publication 3. Recorded by FDA in the Substances Added to Food inventory under CAS 7784-67-0.
Structure
Identity
Also known as: Benzene, 1-ethoxy-2-methoxy-4-(1-propen-1-yl)-, Benzene, 1-ethoxy-2-methoxy-4-propenyl-, Benzene, 1-ethoxy-2-methoxy-4-(1-propenyl)-, 1-Ethoxy-2-methoxy-4-(1-propen-1-yl)benzene, 2-Ethoxy-5-propenylanisole, Ethylisoeugenol, Isoeugenol ethyl ether, O-Ethylisoeugenol, NSC 142123, 2-Methoxy-4-prop-1-enylphenetole, benzene, 1-ethoxy-2-methoxy-4-(1-propen-1-yl)-, benzene, 1-ethoxy-2-methoxy-4-(1-propenyl)-.
Can Isoeugenyl ethyl ether be labeled natural?
Isoeugenyl ethyl ether occurs in nature, so the label depends on the route: isoeugenyl ethyl ether won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized isoeugenyl ethyl ether is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Isoeugenyl ethyl ether is FEMA GRAS under FEMA number 2472. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 04.017, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1267, evaluated at the 61st meeting in 2003. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Isoeugenyl ethyl ether appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 7784-67-0, where EPA names it Benzene, 1-ethoxy-2-methoxy-4-(1-propen-1-yl)-.
Inactive in US commerce
EPA designates this substance inactive, so a Notice of Activity Form B is required before anyone manufactures or processes it again. Being FEMA GRAS does not change that. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, floral, fruity, herbal.
Where it is used
Isoeugenyl ethyl ether is used in beverage, confection, flavoring and cosmetics, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Isoeugenyl ethyl ether by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Isoeugenyl methyl ether | 2476 | 89% | In nature |
| Propenylguaethol | 2922 | 85% | In nature |
| 4-Propenyl-2,6-dimethoxyphenol | 3728 | 76% | In nature |
| Isoeugenyl benzyl ether | 3698 | 74% | Not determined |
| Isoeugenol | 2468 | 67% | In nature |
More ethers in this index
Benzyl butyl ether · Digeranyl ether · Hydroquinone monoethyl ether · Isoamyl phenethyl ether · 1,1-Dipropoxyethane · 1,1-Dimethoxyethane
Isoeugenyl ethyl ether FAQ
Is isoeugenyl ethyl ether FEMA GRAS?
Yes. The FEMA Expert Panel lists isoeugenyl ethyl ether as GRAS under FEMA number 2472. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for isoeugenyl ethyl ether?
Isoeugenyl ethyl ether is FEMA 2472, CAS 7784-67-0. FEMA files it in the fruity flavor category.
Does isoeugenyl ethyl ether count as natural in the US and the EU?
Since isoeugenyl ethyl ether is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when isoeugenyl ethyl ether is synthesized. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
Is isoeugenyl ethyl ether on the EU Union List?
Isoeugenyl ethyl ether is on the EU Union List of flavouring substances as FL 04.017 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated isoeugenyl ethyl ether?
Yes. JECFA number 1267, evaluated at the 61st meeting in 2003. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
How is isoeugenyl ethyl ether described, and where does it show up?
Flavorists describe isoeugenyl ethyl ether as sweet, floral, fruity, herbal. It is used in beverage, confection, flavoring and cosmetics.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ISOEUGENYL ETHYL ETHER under CAS 7784-67-0 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.