Flavor ingredient regulatory record
Methyl N,N-dimethylanthranilate
Methyl N,N-dimethylanthranilate is an ester in the fruity family, FEMA GRAS under FEMA number 4169 (CAS 10072-05-6). Its odor is sweet, fruity, floral, grape, berry.
- FEMA
- 4169
- CAS
- 10072-05-6
- JECFA
- 1551
- EU FL
- 09.648
- Formula
- C10H13NO2
- EC
- 233-202-4
GRAS status: FEMA GRAS, publication 22. Recorded by FDA in the Substances Added to Food inventory under CAS 10072-05-6.
Structure
Identity
Also known as: Benzoic acid, 2-(dimethylamino)-, methyl ester, Anthranilic acid, N,N-dimethyl-, methyl ester, Methyl o-(dimethylamino)benzoate, Methyl 2-(dimethylamino)benzoate, NSC 97545, N,N-Dimethylanthranilic acid methyl ester, methyl 2-(dimethylamino)benzoate, benzoic acid, 2-(dimethylamino)-, methyl ester, methyl o-(dimethylamino)benzoate, ai3-05573, methyl n,n-dimethylanthranilate [fhfi], methyl n,n-dimethylanthranilic acid.
Can Methyl N,N-dimethylanthranilate be labeled natural?
Nature makes Methyl N,N-dimethylanthranilate, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial Methyl N,N-dimethylanthranilate, same molecule. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Methyl N,N-dimethylanthranilate is FEMA GRAS under FEMA number 4169. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 09.648, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1551, evaluated at the 65th meeting in 2005. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, floral, grape, berry.
Where it is used
Methyl N,N-dimethylanthranilate is used in beverage, confection, fruit flavors, flavoring agents and candies, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Methyl N,N-dimethylanthranilate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Methyl N-methylanthranilate | 2718 | 79% | In nature |
| Methyl nicotinate | 3709 | 75% | In nature |
| Piperine | 2909 | 53% | In nature |
| Pyrrolidino-[1,2e]-4H-2,4-dimethyl-1,3,5-dithiazine | 4321 | 52% | In nature |
| Tripropylamine | 4247 | 50% | Not determined |
More esters in this index
Propyleneglycol mono-2-methylbutyrate · Isobornyl acetate · Allyl phenoxyacetate · Anisyl phenylacetate · 1-Octen-3-yl acetate · Isopropyl cinnamate
Methyl N,N-dimethylanthranilate FAQ
Is Methyl N,N-dimethylanthranilate on the FEMA GRAS list?
It is. FEMA number 4169 covers Methyl N,N-dimethylanthranilate. The Code of Federal Regulations lists it at 21 CFR 172.515.
What is the FEMA number for Methyl N,N-dimethylanthranilate?
The FEMA number for Methyl N,N-dimethylanthranilate is 4169 and its CAS registry number is 10072-05-6. Its flavor category is fruity.
What is Methyl N,N-dimethylanthranilate used for?
Methyl N,N-dimethylanthranilate is described as sweet, fruity, floral, grape, berry. It shows up in beverage, confection, fruit flavors, flavoring agents and candies.
What did JECFA conclude about Methyl N,N-dimethylanthranilate?
JECFA evaluated Methyl N,N-dimethylanthranilate at the 65th meeting in 2005 under JECFA number 1551. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Is Methyl N,N-dimethylanthranilate approved in the EU?
Yes. FL 09.648 is the Union List entry for Methyl N,N-dimethylanthranilate, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Is Methyl N,N-dimethylanthranilate natural or artificial?
The process decides for Methyl N,N-dimethylanthranilate. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic Methyl N,N-dimethylanthranilate is artificial. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as METHYL N,N-DIMETHYLANTHRANILATE under CAS 10072-05-6 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.