Flavor ingredient regulatory record

Sodium 2-(4-methoxyphenoxy)propanoate

Sodium 2-(4-methoxyphenoxy)propanoate is an ester in the fruity family, FEMA GRAS under FEMA number 3773 (CAS 150436-68-3). Its odor is sweet, fruity, floral, estery, aromatic.

FEMA
3773
CAS
150436-68-3
JECFA
1029
EU FL
16.041
Formula
C10H11NaO4

GRAS status: FEMA GRAS, publication 15, 16, 17. Recorded by FDA in the Substances Added to Food inventory under CAS 150436-68-3.

Structure

2D structure of Sodium 2-(4-methoxyphenoxy)propanoate
Structure of Sodium 2-(4-methoxyphenoxy)propanoate, C10H11NaO4. Drawn from the canonical SMILES.

Identity

IUPAC name sodium 2-(4-methoxyphenoxy)propanoate
CAS number 150436-68-3
FEMA number 3773
Molecular formula C10H11NaO4
Molecular weight 218.18 g/mol
SMILES COc1ccc(OC(C)C(=O)[O-])cc1.[Na+]
InChIKey SKORRGYRKQDXRS-UHFFFAOYSA-M
PubChem CID 23670520
FDA UNII ZU3D90W5GZ
Chemical class Ester

Also known as: Propanoic acid, 2-(4-methoxyphenoxy)-, sodium salt (1:1), Propanoic acid, 2-(4-methoxyphenoxy)-, sodium salt, (±)-, Propanoic acid, 2-(4-methoxyphenoxy)-, sodium salt, Sodium 2-(4-Methoxyphenoxy)propionate, Lactisole, Envision, envision, propanoic acid, 2-(4-methoxyphenoxy)-, sodium salt (1:1), sodium 2-(4-methoxyphenoxy) propionate, sodium 2-(4-methoxyphenoxy)propionate, lactisole sodium salt [mi], sodium 2-(4-methoxyphenoxy)propanoate [fhfi].

Can Sodium 2-(4-methoxyphenoxy)propanoate be labeled natural?

Nature makes sodium 2-(4-methoxyphenoxy)propanoate, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial sodium 2-(4-methoxyphenoxy)propanoate, same molecule. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.

United States
Natural or artificial, by process
European Union and UK
Natural only from natural material
Mercosur and Mexico
Natural or identical-to-natural

How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.

Regulatory status, with citations

United States

Sodium 2-(4-methoxyphenoxy)propanoate is FEMA GRAS under FEMA number 3773. It is cited in the Code of Federal Regulations at 21 CFR 172.515.

21 CFR 172.515

European Union and United Kingdom

Listed on the Union List of flavouring substances as FL 16.041, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.

JECFA (WHO / FAO)

JECFA number 1029, evaluated at the 87th meeting in 2019. no safety concern at current levels of intake.

JECFA monograph

Other US flags

Not on the California Proposition 65 list.

Odor and taste

Odor: Sweet, fruity, floral, estery, aromatic.

Where it is used

Sodium 2-(4-methoxyphenoxy)propanoate is used in beverage, confection, fruit flavors, bakery and dairy, typically as a fruity note.

Sodium 2-(4-methoxyphenoxy)propanoate FAQ

Is sodium 2-(4-methoxyphenoxy)propanoate on the FEMA GRAS list?

It is. FEMA number 3773 covers sodium 2-(4-methoxyphenoxy)propanoate. The Code of Federal Regulations lists it at 21 CFR 172.515.

What is the FEMA number for sodium 2-(4-methoxyphenoxy)propanoate?

The FEMA number for sodium 2-(4-methoxyphenoxy)propanoate is 3773 and its CAS registry number is 150436-68-3. Its flavor category is fruity.

What is sodium 2-(4-methoxyphenoxy)propanoate used for?

Sodium 2-(4-methoxyphenoxy)propanoate is described as sweet, fruity, floral, estery, aromatic. It shows up in beverage, confection, fruit flavors, bakery and dairy.

What did JECFA conclude about sodium 2-(4-methoxyphenoxy)propanoate?

JECFA evaluated sodium 2-(4-methoxyphenoxy)propanoate at the 87th meeting in 2019 under JECFA number 1029. The panel concluded: no safety concern at current levels of intake.

Is sodium 2-(4-methoxyphenoxy)propanoate approved in the EU?

Yes. FL 16.041 is the Union List entry for sodium 2-(4-methoxyphenoxy)propanoate, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.

Is sodium 2-(4-methoxyphenoxy)propanoate natural or artificial?

The process decides for sodium 2-(4-methoxyphenoxy)propanoate. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic sodium 2-(4-methoxyphenoxy)propanoate is artificial. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.

Ingredient lookup

Check an ingredient

Start typing to search the ingredient corpus.

Or browse every ingredient page, A to Z.

Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification

Check Sodium 2-(4-methoxyphenoxy)propanoate in a formula

Screened against FEMA GRAS, 21 CFR and EU rules as you build. Free to start.

Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as SODIUM 2-(4-METHOXYPHENOXY)PROPANOATE under CAS 150436-68-3 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.

A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.

Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.

About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.