Flavor ingredient regulatory record
Trimethylamine
Trimethylamine is an amine in the savory family, FEMA GRAS under FEMA number 3241 (CAS 75-50-3). Its odor is fishy, pungent, ammonia-like, earthy.
- FEMA
- 3241
- CAS
- 75-50-3
- JECFA
- 1610
- EU FL
- 11.009
- Formula
- C3H9N
- EC
- 200-875-0
GRAS status: FEMA GRAS, publication 4. Recorded by FDA in the Substances Added to Food inventory under CAS 75-50-3.
Structure
Identity
Also known as: Methanamine, N,N-dimethyl-, N,N-Dimethylmethanamine, N-Trimethylamine, N,N,N-Trimethylamine, TM-CP 350, n,n-dimethylmethanamine, methanamine, n,n-dimethyl-, n-trimethylamine, dimethylmethaneamine, (ch3)3n, trimethylamine, anhydrous, n,n,n-trimethylamine.
Can Trimethylamine be labeled natural?
Nature makes trimethylamine, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial trimethylamine, same molecule. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Trimethylamine is FEMA GRAS under FEMA number 3241. It is cited in the Code of Federal Regulations at 21 CFR 173.20.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 11.009, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1610, evaluated at the 65th meeting in 2005. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Trimethylamine appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 75-50-3, where EPA names it Methanamine, N,N-dimethyl-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Fishy, pungent, ammonia-like, earthy.
Taste: Umami, salty, savory.
Where it is used
Trimethylamine is used in seasoning, sauces, meat products and fermented foods, typically as a savory note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Trimethylamine by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Trimethylamine oxide | 4245 | 83% | In nature |
| Acetone | 3326 | 83% | In nature |
| Isopropyl alcohol | 2929 | 81% | In nature |
| Isopropylamine | 4238 | 80% | In nature |
| Triethylamine | 4246 | 71% | In nature |
More amines in this index
Ammonia · Isopropylamine · Triethylamine · Isopentylidene isopentylamine · Piperidine · sec-Butylamine
Trimethylamine FAQ
Does trimethylamine have FEMA GRAS status?
Trimethylamine holds FEMA GRAS status under FEMA number 3241. The Code of Federal Regulations lists it at 21 CFR 173.20.
How do I cite trimethylamine by FEMA or CAS number?
Cite trimethylamine as FEMA 3241 or CAS 75-50-3; both point to the same entry. Its flavor category is savory.
What does trimethylamine smell and taste like, and where is it used?
The odor of trimethylamine is fishy, pungent, ammonia-like, earthy. On the palate it is umami, salty, savory. Typical uses are seasoning, sauces, meat products and fermented foods.
What did JECFA conclude about trimethylamine?
JECFA evaluated trimethylamine at the 65th meeting in 2005 under JECFA number 1610. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Can trimethylamine be used in the EU and UK?
Yes. FL 11.009 is the Union List entry for trimethylamine, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Can trimethylamine be labeled a natural flavor?
The process decides for trimethylamine. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic trimethylamine is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as TRIMETHYLAMINE under CAS 75-50-3 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.