Flavor ingredient regulatory record
2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine
2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine is a natural complex flavoring material in the savory family, FEMA GRAS under FEMA number 3782 (CAS 104691-40-9). Its odor is earthy, sulfurous, savory, umami.
- FEMA
- 3782
- CAS
- 104691-40-9
- JECFA
- 1047
- EU FL
- 15.057
GRAS status: FEMA GRAS, publication 16. Recorded by FDA in the Substances Added to Food inventory under CAS 977161-99-1.
Structure
Material
2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine is a natural complex material rather than a single molecule, so it has no one structure. FEMA lists it as 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine (mixture).
Identity
Also known as: 4H-1,3,5-Dithiazine, dihydro-4,6-dimethyl-2-(1-methylethyl)-, Dihydro-4,6-dimethyl-2-(1-methylethyl)-4H-1,3,5-dithiazine, 2-Isopropyl-4,6-dimethyldihydro-1,3,5-dithiazine, 2-Isopropyl-4,6-dimethyl-1,3,5-dithiazinane, 2-isopropyl-4,6-dimethyldihydro-1,3,5-dithiazine, 2-isopropyl-4,6-dimethyl-1,3,5-dithiazinane, 4h-1,3,5-dithiazine, dihydro-4,6-dimethyl-2-(1-methylethyl)-, 4,6-dimethyl-2-(propan-2-yl)-1,3,5-dithiazinane, dihydro-4,6-dimethyl-2-(1-methylethyl)-4h-1,3,5-dithiazine, 4,6-dimethyl-2-propan-2-yl-1,3,5-dithiazinane, 5,6-dihydro-4,6-dimethyl-2-isopropyl-4h-1,3,5-dithiazine, 4,6-dimethyl-2-(1-methyl ethyl) dihydro-1,3,5-dithiazine.
Can 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine be labeled natural?
Since 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine is synthesized. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine is FEMA GRAS under FEMA number 3782. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 15.057, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
Purity. At least 44 % isopropyl-4,6-dimethyl and 27 % 4-isopropyl-2,6-dimethyl; secondary components at least 24 % 2,4,6-trimethyldihydro-1,3,5-dithiazine; 6-methyl-2,4- diisopropyl-1,3,5-dithiazine; 4-methyl-2,6- diisopropyl-1,3,5-dithiazine; 2,4,6-triisopropyl-dihydro-1,3,5-dithiazine
JECFA (WHO / FAO)
JECFA number 1047, evaluated at the 59th meeting in 2002. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Earthy, sulfurous, savory, umami.
Taste: Savory, rich, complex.
Where it is used
2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine is used in sauces, seasonings, meat products and snack foods, typically as a savory note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-Ethyl-4,6-dimethyl-dihydro-1,3,5-dithiazine | 4667 | 86% | Not determined |
| 4,5-Dimethyl-2-ethyl-3-thiazoline | 3620 | 82% | In nature |
| Triethylthialdine | 4748 | 80% | Not determined |
| 2-Ethyl-2,5-dihydro-4-methylthiazole | 4695 | 80% | Not determined |
| 2-(2-Butyl)-4,5-dimethyl-3-thiazoline | 3619 | 76% | In nature |
More thiols in this index
2-Ethyl-4,6-dimethyl-dihydro-1,3,5-dithiazine · 2-Isobutyl-4,6-dimethyldihydro-1,3,5-dithiazine and 4-isobutyl-2,6-dimethyldihydro-1,3,5-dithiazine · l-Cysteine · 2-Acetyl-5-methylthiophene · 2-Ethylthiophenol · (+/-)-2-Mercaptomethylpentan-1-ol
2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine FAQ
Is 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine on the FEMA GRAS list?
It is. FEMA number 3782 covers 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine. It is also codified at 21 CFR 172.515.
What is the FEMA number for 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine?
The FEMA number for 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine is 3782 and its CAS registry number is 104691-40-9. FEMA files it in the savory flavor category.
Is 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine natural or artificial?
2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine occurs in nature, so the label depends on the route: 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine is artificial. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
Is 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine approved in the EU?
2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine is on the EU Union List of flavouring substances as FL 15.057 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine?
Yes. JECFA number 1047, evaluated at the 59th meeting in 2002. Conclusion: no safety concern at current levels of intake.
What is 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine used for?
2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine is described as earthy, sulfurous, savory, umami. On the palate it is savory, rich, complex. It shows up in sauces, seasonings, meat products and snack foods.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2(4)-ISOPROPYL-4(2),6-DIMETHYLDIHYDRO-4H-1,3,5-DITHIAZINE under CAS 977161-99-1 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.