Flavor ingredient regulatory record
4,5-Dimethyl-2-ethyl-3-thiazoline
4,5-Dimethyl-2-ethyl-3-thiazoline is a thiazoline in the savory family, FEMA GRAS under FEMA number 3620 (CAS 76788-46-0). Its odor is savory, meaty, roasted, umami.
- FEMA
- 3620
- CAS
- 76788-46-0
- JECFA
- 1058
- Formula
- C7H13NS
- EC
- 278-551-3
GRAS status: FEMA GRAS, publication 12. Recorded by FDA in the Substances Added to Food inventory under CAS 76788-46-0.
Structure
Identity
Also known as: Thiazole, 2-ethyl-2,5-dihydro-4,5-dimethyl-, 3-Thiazoline, 2-ethyl-4,5-dimethyl-, 2-Ethyl-2,5-dihydro-4,5-dimethylthiazole, 2-Ethyl-4,5-dimethyl-2,5-dihydro-1,3-thiazole, 2-Ethyl-4,5-dimethyl-2,5-dihydrothiazole, 2-ethyl-2,5-dihydro-4,5-dimethylthiazole, 2-ethyl-4,5-dimethyl-3-thiazoline, 2-ethyl-4,5-dimethyl thiazoline, 3-thiazoline, 4,5-dimethyl-2-ethyl-, thiazole, 2,5-dihydro-4,5-dimethyl-2-ethyl-, thiazole, 2-ethyl-2,5-dihydro-4,5-dimethyl-, 3-thiazoline, 2-ethyl-4,5-dimethyl-.
Can 4,5-Dimethyl-2-ethyl-3-thiazoline be labeled natural?
4,5-Dimethyl-2-ethyl-3-thiazoline occurs in nature, so the label depends on the route: 4,5-Dimethyl-2-ethyl-3-thiazoline won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized 4,5-Dimethyl-2-ethyl-3-thiazoline is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic 4,5-Dimethyl-2-ethyl-3-thiazoline identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
4,5-Dimethyl-2-ethyl-3-thiazoline is FEMA GRAS under FEMA number 3620. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
4,5-Dimethyl-2-ethyl-3-thiazoline was on the Union List of flavouring substances as FL 15.030 when Regulation (EU) 872/2012 adopted the list, and the entry has since been withdrawn. It does not appear in the current consolidated text of Regulation (EC) 1334/2008. Check the amending regulations for the conditions that applied to existing stock, and treat EU or UK use as closed unless another route covers it.
JECFA (WHO / FAO)
JECFA number 1058, evaluated at the 59th meeting in 2002. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Savory, meaty, roasted, umami.
Where it is used
4,5-Dimethyl-2-ethyl-3-thiazoline is used in savory snacks, seasonings, meat products and sauces, typically as a savory note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 4,5-Dimethyl-2-ethyl-3-thiazoline by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-Ethyl-2,5-dihydro-4-methylthiazole | 4695 | 94% | Not determined |
| 2-(2-Butyl)-4,5-dimethyl-3-thiazoline | 3619 | 86% | In nature |
| 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine | 3782 | 82% | In nature |
| cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline | 4318 | 82% | Not determined |
| 2,4,5-Trimethyl-delta-3-oxazoline | 3525 | 75% | In nature |
More thiazolines in this index
2-Acetyl-2-thiazoline · 4-Methyl-3-thiazoline · 4,5-Dimethyl-2-isobutyl-3-thiazoline · 2-(2-Butyl)-4,5-dimethyl-3-thiazoline · cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline · cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline
4,5-Dimethyl-2-ethyl-3-thiazoline FAQ
Is 4,5-Dimethyl-2-ethyl-3-thiazoline on the FEMA GRAS list?
It is. FEMA number 3620 covers 4,5-Dimethyl-2-ethyl-3-thiazoline. It is also codified at 21 CFR 172.515.
What is the FEMA number for 4,5-Dimethyl-2-ethyl-3-thiazoline?
The FEMA number for 4,5-Dimethyl-2-ethyl-3-thiazoline is 3620 and its CAS registry number is 76788-46-0. FEMA files it in the savory flavor category.
Is 4,5-Dimethyl-2-ethyl-3-thiazoline natural or artificial?
Since 4,5-Dimethyl-2-ethyl-3-thiazoline is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when 4,5-Dimethyl-2-ethyl-3-thiazoline is synthesized. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic 4,5-Dimethyl-2-ethyl-3-thiazoline identical-to-natural.
Is 4,5-Dimethyl-2-ethyl-3-thiazoline approved in the EU?
No EU FL number is on file for 4,5-Dimethyl-2-ethyl-3-thiazoline. It has a JECFA evaluation (JECFA 1058), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Has JECFA evaluated 4,5-Dimethyl-2-ethyl-3-thiazoline?
Yes. JECFA number 1058, evaluated at the 59th meeting in 2002. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What is 4,5-Dimethyl-2-ethyl-3-thiazoline used for?
4,5-Dimethyl-2-ethyl-3-thiazoline is described as savory, meaty, roasted, umami. It shows up in savory snacks, seasonings, meat products and sauces.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 4,5-DIMETHYL-2-ETHYL-3-THIAZOLINE under CAS 76788-46-0 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavor enhancer, flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.