Flavor ingredient regulatory record
cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline
cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline is a thiazoline in the fruity family, FEMA GRAS under FEMA number 4319 (CAS 83418-53-5). Its odor is sweet, fruity, nutty, earthy, herbal.
- FEMA
- 4319
- CAS
- 83418-53-5
- JECFA
- 1761
- Formula
- C10H19NS
- EC
- 639-230-7
GRAS status: FEMA GRAS, publication 23. Recorded by FDA in the Substances Added to Food inventory under CAS 83418-53-5.
Structure
Identity
Also known as: Thiazole, 5-ethyl-2,5-dihydro-4-methyl-2-(2-methylpropyl)-, 5-Ethyl-2,5-dihydro-4-methyl-2-(2-methylpropyl)thiazole, 5-ethyl-4-methyl-2-(2-methylpropyl)-2,5-dihydro-1,3-thiazole.
Can cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline is FEMA GRAS under FEMA number 4319. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline was on the Union List of flavouring substances as FL 15.130 when Regulation (EU) 872/2012 adopted the list, and the entry has since been withdrawn. It does not appear in the current consolidated text of Regulation (EC) 1334/2008. Check the amending regulations for the conditions that applied to existing stock, and treat EU or UK use as closed unless another route covers it.
JECFA (WHO / FAO)
JECFA number 1761.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, nutty, earthy, herbal.
Where it is used
cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline is used in beverage, savory snacks, seasonings and condiments, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 4,5-Dimethyl-2-isobutyl-3-thiazoline | 3621 | 93% | In nature |
| cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline | 4318 | 92% | Not determined |
| 2-(2-Butyl)-4,5-dimethyl-3-thiazoline | 3619 | 82% | In nature |
| 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine | 3782 | 71% | In nature |
| 2-Isobutyl-4,5-dimethyloxazole | 4397 | 70% | In nature |
More thiazolines in this index
cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline · 2-(2-Butyl)-4,5-dimethyl-3-thiazoline · 4,5-Dimethyl-2-isobutyl-3-thiazoline · 4-Methyl-3-thiazoline · 2-Acetyl-2-thiazoline · 4,5-Dimethyl-2-ethyl-3-thiazoline
cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline FAQ
Is cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline on the FEMA GRAS list?
It is. FEMA number 4319 covers cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline. The Code of Federal Regulations lists it at 21 CFR 172.515.
What is the FEMA number for cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline?
The FEMA number for cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline is 4319 and its CAS registry number is 83418-53-5. Its flavor category is fruity.
What is cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline used for?
cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline is described as sweet, fruity, nutty, earthy, herbal. It shows up in beverage, savory snacks, seasonings and condiments.
What did JECFA conclude about cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline?
JECFA evaluated cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline under JECFA number 1761.
Is cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline approved in the EU?
No EU FL number is on file for cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline. It has a JECFA evaluation (JECFA 1761), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as CIS AND TRANS-5-ETHYL-4-METHYL-2-(2-METHYLPROPYL)-THIAZOLINE under CAS 83418-53-5 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.