Flavor ingredient regulatory record
cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline
cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline is a thiazoline in the fruity family, FEMA GRAS under FEMA number 4318 (CAS 83418-54-6). Its odor is sweet, fruity, nutty, herbaceous, earthy.
- FEMA
- 4318
- CAS
- 83418-54-6
- JECFA
- 1762
- EC
- 639-229-1
GRAS status: FEMA GRAS, publication 23. Recorded by FDA in the Substances Added to Food inventory under CAS 83418-54-6.
Structure
Under review
The structure for cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline is still under identity review, so no drawing is shown until the record is confirmed.
Identity
Also known as: Thiazole, 5-ethyl-2,5-dihydro-4-methyl-2-(1-methylpropyl)-, 5-Ethyl-2,5-dihydro-4-methyl-2-(1-methylpropyl)thiazole.
Can cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline is FEMA GRAS under FEMA number 4318. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline was on the Union List of flavouring substances as FL 15.131 when Regulation (EU) 872/2012 adopted the list, and the entry has since been withdrawn. It does not appear in the current consolidated text of Regulation (EC) 1334/2008. Check the amending regulations for the conditions that applied to existing stock, and treat EU or UK use as closed unless another route covers it.
JECFA (WHO / FAO)
JECFA number 1762, evaluated at the 68th meeting in 2007. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, nutty, herbaceous, earthy.
Where it is used
cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline is used in beverage, savory snacks, seasonings and sauces, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-(2-Butyl)-4,5-dimethyl-3-thiazoline | 3619 | 94% | In nature |
| cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline | 4319 | 92% | Not determined |
| 4,5-Dimethyl-2-isobutyl-3-thiazoline | 3621 | 86% | In nature |
| 4,5-Dimethyl-2-ethyl-3-thiazoline | 3620 | 82% | In nature |
| 2-Isopropyl-4,6-dimethyl and 4-Isopropyl-2,6-dimethyldihydro-1,3,5-dithiazine | 3782 | 73% | In nature |
More thiazolines in this index
2-(2-Butyl)-4,5-dimethyl-3-thiazoline · cis- and trans-5-Ethyl-4-methyl-2-(2-methylpropyl)-thiazoline · 4,5-Dimethyl-2-ethyl-3-thiazoline · 4,5-Dimethyl-2-isobutyl-3-thiazoline · 2-Acetyl-2-thiazoline · 4-Methyl-3-thiazoline
cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline FAQ
Does cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline have FEMA GRAS status?
cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline holds FEMA GRAS status under FEMA number 4318. It is also codified at 21 CFR 172.515.
How do I cite cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline by FEMA or CAS number?
Cite cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline as FEMA 4318 or CAS 83418-54-6; both point to the same entry. FEMA files it in the fruity flavor category.
Is cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline approved in the EU?
No EU FL number is on file for cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline. It has a JECFA evaluation (JECFA 1762), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Has JECFA evaluated cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline?
Yes. JECFA number 1762, evaluated at the 68th meeting in 2007. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What does cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline smell and taste like, and where is it used?
The odor of cis- and trans-5-Ethyl-4-methyl-2-(1-methylpropyl)-thiazoline is sweet, fruity, nutty, herbaceous, earthy. Typical uses are beverage, savory snacks, seasonings and sauces.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as CIS- AND TRANS-5-ETHYL-4-METHYL-2-(2-BUTYL)-THIAZOLINE under CAS 83418-54-6 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.