Flavor ingredient regulatory record
4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid
4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid is an acid in the fruity family, FEMA GRAS under FEMA number 4774 (CAS 1359963-68-0). Its odor is sweet, fruity, floral, herbal, slightly spicy.
- FEMA
- 4774
- CAS
- 1359963-68-0
- JECFA
- 2204
- EU FL
- 16.130
GRAS status: FEMA GRAS. Source: FEMA Flavor Ingredient Library.
Structure
Under review
The structure for 4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid is still under identity review, so no drawing is shown until the record is confirmed.
Identity
Also known as: 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid, 3-quinolinecarboxylic acid, 4-amino-5-(2,2-dimethyl-3-((1-methylethyl)amino)-3-oxopropoxy)-2-methyl-, 3-quinolinecarboxylic acid, 4-amino-5-[2,2-dimethyl-3-[(1-methylethyl)amino]-3-oxopropoxy]-2-methyl-, 4-amino-5-[2,2-dimethyl-3-oxo-3-(propan-2-ylamino)propoxy]-2-methylquinoline-3-carboxylic acid, ex-a3476, ac-36418, ms-25663, db-107026, hy-139091, cs-0179574, 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquino-line-3-carboxylic acid, 4-amino-5-[3-(isopropylamino)-2,2-dimethyl-3-oxo-propoxy]-2-methyl-quinoline-3-carboxylic acid.
Can 4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid is FEMA GRAS under FEMA number 4774. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.130, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list. The entry carries use restrictions.
Use restrictions. Note: Part A, Section 2, Note 1 of Annex I to Regulation (EC) No 1334/2008 does not apply to this substance. Restrictions for use as a flavouring substance expressed as a sum of the carboxylic acid and the hemisulfate monohydrate salt, expressed as the acid: In category 1.4. - not more than 10 mg/kg. In category 1.6.3. - not more than 30 mg/kg. In category 1.8. - not more than 30 mg/kg. In categories 2.2.1. and 2.2.2. - not more than 30 mg/kg. In category 3. - not more than 30 mg/kg. In category 4.2.3. - not more than 10 mg/kg. In category 4.2.4.1. - not more than 30 mg/kg. In category 4.2.4.2. - not more than 10 mg/kg. In categories 4.2.5.1., 4.2.5.2., 4.2.5.3. and 4.2.5.4. - not more than 30 mg/kg. In categories 5.1. and 5.2. - not more than 30 mg/kg. In category 5.3. - not more than 300 mg/kg. In category 5.4. - not more than 30 mg/kg. In category 6.3. - not more than 45 mg/kg. In category 7.2. - not more than 15 mg/kg. In categories 8.3.1, 8.3.2. and 8.3.3. - not more than 15 mg/kg. In categories 8.3.4.1., 8.3.4.2. and 8.3.4.3. - not more than 15 mg/kg. In category 11.2. - not more than 30 mg/kg. In category 12.4. - not more than 30 mg/kg. In category 12.5. - not more than 10 mg/l. In categories 14.1.2., 14.1.3. and 14.1.4. - not more than 7 mg/l. In categories 14.1.5.1. and 14.1.5.2. - not more than 7 mg/kg. In category 14.2.1. - not more than 7 mg/l. In categories 14.2.2. and 14.2.5. - not more than 10 mg/l. In category 15.1. - not more than 30 mg/kg. In category 16 (excluding products covered in categories 1, 3 and 5) - not more than 15 mg/kg.
Purity. At least 99 % minimum assay (IR NMR MS)
JECFA (WHO / FAO)
JECFA number 2204, evaluated at the 79th meeting in 2014. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, floral, herbal, slightly spicy.
Taste: Sour, umami, slightly bitter.
Where it is used
4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid is used in beverage, confection, savory dishes and snacks, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Trilobatin | 4674 | 70% | In nature |
| Naringin dihydrochalcone | 4495 | 69% | Not determined |
| N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide | 4231 | 68% | Not determined |
| N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(5-methylpyridin-2-yl)ethyl)oxalamide | 4234 | 65% | Not determined |
More acids in this index
cis- and trans-2-Heptylcyclopropanecarboxylic acid · 4-Methoxybenzoic acid · 3-Isopropenylpentanedioic acid · 2-Methylvaleric acid · Mixture of Ricinoleic acid, Linoleic acid, and Oleic acid · (E)-2-Pentenoic acid
4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid FAQ
Does 4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid have FEMA GRAS status?
4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid holds FEMA GRAS status under FEMA number 4774. It is also codified at 21 CFR 172.515.
How do I cite 4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid by FEMA or CAS number?
Cite 4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid as FEMA 4774 or CAS 1359963-68-0; both point to the same entry. FEMA files it in the fruity flavor category.
Can 4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid be used in the EU and UK?
4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid is on the EU Union List of flavouring substances as FL 16.130 (Annex I Part A) under Regulation 1334/2008. Its entry carries use restrictions, listed on this page.
Has JECFA evaluated 4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid?
Yes. JECFA number 2204, evaluated at the 79th meeting in 2014. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What does 4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid smell and taste like, and where is it used?
The odor of 4-Amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid is sweet, fruity, floral, herbal, slightly spicy. On the palate it is sour, umami, slightly bitter. Typical uses are beverage, confection, savory dishes and snacks.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The FEMA number and GRAS status on this page name a conclusion reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States. FDA does not list this substance by FEMA number in its Substances Added to Food inventory. Its identity is attested by EU Union List of flavouring substances, matched on CAS 1359963-68-0.
FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.