Flavor ingredient regulatory record
N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide
N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide is an amide in the fruity family, FEMA GRAS under FEMA number 4231 (CAS 745047-97-6). Its odor is sweet, fruity, floral, herbal, spicy.
- FEMA
- 4231
- CAS
- 745047-97-6
- JECFA
- 1770
- EU FL
- 16.101
- Formula
- C18H21N3O3
GRAS status: FEMA GRAS, publication 22. Recorded by FDA in the Substances Added to Food inventory under CAS 745047-97-6.
Structure
Identity
Also known as: Ethanediamide, N1-[(2-methoxy-4-methylphenyl)methyl]-N2-[2-(2-pyridinyl)ethyl]-, Ethanediamide, N-[(2-methoxy-4-methylphenyl)methyl]-N′-[2-(2-pyridinyl)ethyl]-, N1-[(2-Methoxy-4-methylphenyl)methyl]-N2-[2-(2-pyridinyl)ethyl]ethanediamide, n1-(2-methoxy-4-methylbenzyl)-n2-(2-(pyridin-2-yl) ethyl)oxalamide, n'-((2-methoxy-4-methyl-phenyl)methyl)-n-(2-(2-pyridyl)ethyl)oxamide, ethanediamide, n-((2-methoxy-4-methylphenyl)methyl)-n'-(2-(2-pyridinyl)ethyl)-, ethanediamide, n1-((2-methoxy-4-methylphenyl)methyl)-n2-(2-(2-pyridinyl)ethyl)-, n1-(2-methoxy-4-methylbenzyl)-n2-(2-(pyridin-2-yl)ethyl)oxalamide [fhfi], n-[(2-methoxy-4-methylphenyl)methyl]-n'-[2-(pyridin-2-yl)ethyl]ethanediamide, n-((2-methoxy-4-methylphenyl)methyl)-n'-(2-(2-pyridinyl)ethyl)ethanediamide, n-((2-methoxy-4-methylphenyl)methyl)-n'-(2-(pyridin-2-yl)ethyl)ethanediamide, n'-[(2-methoxy-4-methylphenyl)methyl]-n-(2-pyridin-2-ylethyl)oxamide.
Can N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide is FEMA GRAS under FEMA number 4231. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.101, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1770, evaluated at the 68th meeting in 2007. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, floral, herbal, spicy.
Taste: Sweet, savory, herbal.
Where it is used
N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide is used in beverage, confection, savory dishes and snacks, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(5-methylpyridin-2-yl)ethyl)oxalamide | 4234 | 98% | Not determined |
| N1-(2,4-Dimethoxybenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide | 4233 | 92% | Not determined |
| N-(2-(Pyridin-2-yl)ethyl)-3-p-menthanecarboxamide | 4549 | 77% | Not determined |
| Capsaicin | 3404 | 77% | In nature |
| Nonanoyl 4-hydroxy-3-methoxybenzylamide | 2787 | 75% | In nature |
More amides in this index
N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide · (2S,5R)-N-[4-(2-Amino-2-oxoethyl)phenyl]-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide · N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(5-methylpyridin-2-yl)ethyl)oxalamide · N-3,7-Dimethyl-2,6-octadienyl cyclopropylcarboxamide · N-(2-Hydroxyethyl)galactonamide · N1-(2,4-Dimethoxybenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide
N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide FAQ
Does N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide have FEMA GRAS status?
N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide holds FEMA GRAS status under FEMA number 4231. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide by FEMA or CAS number?
Cite N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide as FEMA 4231 or CAS 745047-97-6; both point to the same entry. Its flavor category is fruity.
What does N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide smell and taste like, and where is it used?
The odor of N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide is sweet, fruity, floral, herbal, spicy. On the palate it is sweet, savory, herbal. Typical uses are beverage, confection, savory dishes and snacks.
What did JECFA conclude about N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide?
JECFA evaluated N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide at the 68th meeting in 2007 under JECFA number 1770. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Can N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide be used in the EU and UK?
Yes. FL 16.101 is the Union List entry for N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as N1-(2-METHOXY-4-METHYLBENZYL)-N2-(2-(PYRIDIN-2-YL) ETHYL)OXALAMIDE under CAS 745047-97-6 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.