Flavor ingredient regulatory record
Nonanoyl 4-hydroxy-3-methoxybenzylamide
Nonanoyl 4-hydroxy-3-methoxybenzylamide is an amide in the fruity family, FEMA GRAS under FEMA number 2787 (CAS 2444-46-4). Its odor is sweet, fruity, floral, herbal, nutty.
- FEMA
- 2787
- CAS
- 2444-46-4
- JECFA
- 1599
- EU FL
- 16.006
- Formula
- C17H27NO3
- EC
- 219-484-1
GRAS status: FEMA GRAS, publication 3. Recorded by FDA in the Substances Added to Food inventory under CAS 2444-46-4.
Structure
Identity
Also known as: Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-, Nonanamide, N-vanillyl-, N-[(4-Hydroxy-3-methoxyphenyl)methyl]nonanamide, Nonanoic acid vanillylamide, Pelargonic acid vanillylamide, N-Vanillylnonanamide, N-Vanillylpelargonamide, Vanillyl n-nonylamide, Vanillyl pelargonic amide, N-Vanillylnonamide, Nonylic acid vanillylamide, Nonylic vanillylamide.
Can Nonanoyl 4-hydroxy-3-methoxybenzylamide be labeled natural?
The process decides for nonanoyl 4-hydroxy-3-methoxybenzylamide. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic nonanoyl 4-hydroxy-3-methoxybenzylamide is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Nonanoyl 4-hydroxy-3-methoxybenzylamide is FEMA GRAS under FEMA number 2787. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.006, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1599, evaluated at the 65th meeting in 2005. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Nonanoyl 4-hydroxy-3-methoxybenzylamide appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 2444-46-4, where EPA names it Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, floral, herbal, nutty.
Where it is used
Nonanoyl 4-hydroxy-3-methoxybenzylamide is used in beverage, confection, dairy and flavoring agents, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Nonanoyl 4-hydroxy-3-methoxybenzylamide by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Capsaicin | 3404 | 89% | In nature |
| (1R,2S,5R)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide | 4681 | 76% | Not determined |
| N-(Heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide | 4232 | 76% | Not determined |
| N1-(2,4-Dimethoxybenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide | 4233 | 75% | Not determined |
| N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(5-methylpyridin-2-yl)ethyl)oxalamide | 4234 | 75% | Not determined |
More amides in this index
(2E,6E/Z,8E)-N-(2-Methylpropyl)-2,6,8-decatrienamide · N-Ethyl-2,2-diisopropylbutanamide · N1-(2,4-Dimethoxybenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide · N-p-Benzene acetonitrile-menthane-carboxamide · N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide · 2-Isopropyl-N,2,3-trimethylbutyramide
Nonanoyl 4-hydroxy-3-methoxybenzylamide FAQ
Is nonanoyl 4-hydroxy-3-methoxybenzylamide FEMA GRAS?
Yes. The FEMA Expert Panel lists nonanoyl 4-hydroxy-3-methoxybenzylamide as GRAS under FEMA number 2787. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for nonanoyl 4-hydroxy-3-methoxybenzylamide?
Nonanoyl 4-hydroxy-3-methoxybenzylamide is FEMA 2787, CAS 2444-46-4. Its flavor category is fruity.
How is nonanoyl 4-hydroxy-3-methoxybenzylamide described, and where does it show up?
Flavorists describe nonanoyl 4-hydroxy-3-methoxybenzylamide as sweet, fruity, floral, herbal, nutty. It is used in beverage, confection, dairy and flavoring agents.
What did JECFA conclude about nonanoyl 4-hydroxy-3-methoxybenzylamide?
JECFA evaluated nonanoyl 4-hydroxy-3-methoxybenzylamide at the 65th meeting in 2005 under JECFA number 1599. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Is nonanoyl 4-hydroxy-3-methoxybenzylamide on the EU Union List?
Yes. FL 16.006 is the Union List entry for nonanoyl 4-hydroxy-3-methoxybenzylamide, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Does nonanoyl 4-hydroxy-3-methoxybenzylamide count as natural in the US and the EU?
Nature makes nonanoyl 4-hydroxy-3-methoxybenzylamide, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial nonanoyl 4-hydroxy-3-methoxybenzylamide, same molecule. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as NONANOYL 4-HYDROXY-3-METHOXYBENZYLAMIDE under CAS 2444-46-4 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavor enhancer, flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.