Flavor ingredient regulatory record
N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide
N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide is an amide in the fruity family, FEMA GRAS under FEMA number 4678 (CAS 1003050-32-5). Its odor is sweet, floral, fruity, green, herbaceous.
- FEMA
- 4678
- CAS
- 1003050-32-5
- JECFA
- 2081
- EU FL
- 16.119
- Formula
- C14H14F5NO
GRAS status: FEMA GRAS, publication 25. Recorded by FDA in the Substances Added to Food inventory under CAS 1003050-32-5.
Structure
Identity
Also known as: 2,3,4,5,6-pentafluoro-n-(2-methylcyclohexyl)benzamide, pfmc benzamide, n-(2-methylcyclohexyl)-2,3,4,5,6-pentafluoro-benzamide.
Can N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide is FEMA GRAS under FEMA number 4678. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.119, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list. The entry carries use restrictions.
Use restrictions. Restrictions for use as a flavouring substance: In category 1. - not more than 1 mg/kg; In category 12. - not more than 6 mg/kg; In category 14.1.4. - not more than 3 mg/kg.
Purity. Mixture of cis -/ trans - diastereoisomers: - 60-80 % trans -, consisting of 50 % (1 S ,2 S ) and 50 % (1 R ,2 R ), and - 20-40 % cis -, consisting of 50 % (1 R ,2 S ) and 50 % (1 S ,2 R ).
JECFA (WHO / FAO)
JECFA number 2081, evaluated at the 76th meeting in 2012. No safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, floral, fruity, green, herbaceous.
Taste: Slightly sweet, savory, umami.
Where it is used
N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide is used in beverage, confection, savory dishes and snacks, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| N-(Heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide | 4232 | 29% | Not determined |
| N-Benzoylanthranilic acid | 4078 | 28% | In nature |
| N-[(Ethoxycarbonyl)methyl)-p-menthane-3-carboxamide | 4309 | 28% | Not determined |
| Propyl Gallate | 2947 | 27% | In nature |
| 1-(2-Hydroxy-4-methoxyphenyl)-3-(pyridin-2-yl)propan-1-one | 4723 | 27% | Not determined |
More amides in this index
N-(Heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide · N-(2-Hydroxyethyl)galactonamide · Nonanoyl 4-hydroxy-3-methoxybenzylamide · (2S,5R)-N-[4-(2-Amino-2-oxoethyl)phenyl]-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide · (1R,2S,5R)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide · N-Ethyl-2,2-diisopropylbutanamide
N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide FAQ
Does N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide have FEMA GRAS status?
N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide holds FEMA GRAS status under FEMA number 4678. It is also codified at 21 CFR 172.515.
How do I cite N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide by FEMA or CAS number?
Cite N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide as FEMA 4678 or CAS 1003050-32-5; both point to the same entry. FEMA files it in the fruity flavor category.
Can N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide be used in the EU and UK?
N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide is on the EU Union List of flavouring substances as FL 16.119 (Annex I Part A) under Regulation 1334/2008. Its entry carries use restrictions, listed on this page.
Has JECFA evaluated N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide?
Yes. JECFA number 2081, evaluated at the 76th meeting in 2012. Conclusion: No safety concern at current levels of intake.
What does N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide smell and taste like, and where is it used?
The odor of N-(2-Methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide is sweet, floral, fruity, green, herbaceous. On the palate it is slightly sweet, savory, umami. Typical uses are beverage, confection, savory dishes and snacks.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as N-(2-METHYLCYCLOHEXYL)-2,3,4,5,6-PENTAFLUOROBENZAMIDE under CAS 1003050-32-5 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.