Flavor ingredient regulatory record
2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide
2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide is an amide in the fruity family, FEMA GRAS under FEMA number 4809 (CAS 1374760-95-8). Its odor is sweet, floral, herbal, spicy, earthy.
- FEMA
- 4809
- CAS
- 1374760-95-8
- JECFA
- 2237
- EU FL
- 16.133
- Formula
- C17H17N3O2S
- EC
- 815-961-9
GRAS status: FEMA GRAS. Source: FEMA Flavor Ingredient Library.
Structure
Identity
Also known as: Acetamide, 2-(4-methylphenoxy)-N-1H-pyrazol-3-yl-N-(2-thienylmethyl)-, 2-(4-Methylphenoxy)-N-1H-pyrazol-3-yl-N-(2-thienylmethyl)acetamide, 2-(4-Methylphenoxy)-N-1H-pyrazol-5-yl-N-(2-thienylmethyl)acetamide, FEMA 4809, N-(1H-Pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide, 2-(p-Tolyloxy)-N-(1H-pyrazol-3-yl)-N-[(thien-2-yl)methyl]acetamide, Freezestorm, acetamide, 2-(4-methylphenoxy)-n-1h-pyrazol-3-yl-n-(2-thienylmethyl)-, 2-(4-methylphenoxy)-n-1h-pyrazol-3-yl-n-(2-thienylmethyl)acetamide, n-(1h-pyrazol-5-yl)-n-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide, fema-4809, 2-(4-methylphenoxy)-n-(1h-pyrazol-5-yl)-n-(thiophen-2-ylmethyl)acetamide.
Can 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide is FEMA GRAS under FEMA number 4809. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 16.133, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list. The entry carries use restrictions.
Use restrictions. 1. Restrictions of use as a flavouring substance, in the following food categories: In category 1.4.: Opaque flavoured fermented milk products including heat treated products and packaged in opaque packaging/containers - not more than 3 mg/kg In category 3.0.: opaque edible ices, including sherbet and sorbet, and packaged in opaque packaging/containers - not more than 3 mg/kg In category 5.1.: opaque cocoa products and chocolate products, including imitations and chocolate substitutes, and pacakaged in opaque packaging/containers - not more than 15 mg/kg In category 5.2.: opaque confectionery, including hard and soft candy, nougats, etc., other than products falling in categories 05.1., 05.3. and 05.4, and packaged in opaque packaging/containers - not more than 15 mg/kg In category 5.3: opaque chewing gum, and packaged in opaque packaging/containers - not more than 150 mg/kg In category 5.4.: opaque decorations (e.g. for fine bakery wares), toppings (non¬fruit) and sweet sauces), and packaged in opaque packaging/containers - not more than 15 mg/kg In category 12.5.: opaque soups and broths, and packaged in opaque packaging/containers - not more than 3 mg/kg In category 12.6.: opaque sauces and like products, and packaged in opaque packaging/containers - not more than 15 mg/kg In category 14.1.4.: opaque flavoured drinks, only for dairy based drinks, and packaged in opaque packaging/containers - not more than 3 mg/kg In category 16.: opaque desserts excluding products covered in categories 1., 3. and 4., and packaged in opaque packaging/containers - not more than 3 mg/kg 2. This flavouring substance is not authorised for sale to the final consumer. 3. The following information shall be provided ‘contains substance FL 16.133. Protect from light to avoid its photo-transformation’. Containers shall be opaque. An indication on the containers such as ‘keep away from light’ shall also be included in the labelling.
Purity. At least 99 %, peak area (UPLC-UV, 254 nm)
JECFA (WHO / FAO)
JECFA number 2237.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 1374760-95-8, where EPA names it Acetamide, 2-(4-methylphenoxy)-N-1H-pyrazol-3-yl-N-(2-thienylmethyl)-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA regulatory flags
| Flag | EPA definition | What it obliges |
|---|---|---|
| PMN | Indicates a commenced PMN substance. | Nothing new. The substance already went through premanufacture review and someone filed a notice of commencement, which is why it is on the Inventory. It is an existing chemical and needs no new premanufacture notice. Read more |
| SP | Indicates a substance that is identified in a proposed Significant New Use Rule. | No significant new use notice yet. Export notification under TSCA section 12(b) already applies, because 40 CFR 721.20 reaches substances named in a proposed rule as well as a final one. Read more |
PMN does not establish: The flag records how the substance arrived, not what may be done with it. Check the flags beside it.
SP does not establish: A proposed rule may change or may never be finalized. Read the proposal.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, floral, herbal, spicy, earthy.
Taste: Savory, slightly bitter, herbal.
Where it is used
2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide is used in beverage, savory dishes, snacks and seasonings, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide | 4788 | 59% | Not determined |
| 3-(1-((3,5-Dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)-imidazolidine-2,4-dione | 4725 | 59% | Not determined |
| Piperine | 2909 | 57% | In nature |
| 4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one | 4669 | 56% | Not determined |
| Theobromine | 3591 | 52% | In nature |
More amides in this index
N-Cyclopropyl (E)-2,(Z)-6-nonadienamide · N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(5-methylpyridin-2-yl)ethyl)oxalamide · N-(Heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide · Nonanoyl 4-hydroxy-3-methoxybenzylamide · N-Ethyl-2,2-diisopropylbutanamide · N1-(2-Methoxy-4-methylbenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide
2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide FAQ
Is 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide FEMA GRAS?
Yes. The FEMA Expert Panel lists 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide as GRAS under FEMA number 4809. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide?
2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide is FEMA 4809, CAS 1374760-95-8. Its flavor category is fruity.
How is 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide described, and where does it show up?
Flavorists describe 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide as sweet, floral, herbal, spicy, earthy. On the palate it is savory, slightly bitter, herbal. It is used in beverage, savory dishes, snacks and seasonings.
What did JECFA conclude about 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide?
JECFA evaluated 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide under JECFA number 2237.
Is 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide on the EU Union List?
Yes. FL 16.133 is the Union List entry for 2-(4-Methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list. Its entry carries use restrictions, listed on this page.
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Sources and attribution. The FEMA number and GRAS status on this page name a conclusion reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States. FDA does not list this substance by FEMA number in its Substances Added to Food inventory. Its identity is attested by EU Union List of flavouring substances, EPA TSCA Chemical Substance Inventory, matched on CAS 1374760-95-8.
FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.