Flavor ingredient regulatory record
Acetaldehyde di-cis-3-hexenyl acetal
Acetaldehyde di-cis-3-hexenyl acetal is an acetal in the fruity family, FEMA GRAS under FEMA number 4381 (CAS 63449-64-9). Its odor is sweet, fruity, green, fresh, floral.
- FEMA
- 4381
- CAS
- 63449-64-9
- JECFA
- 1747
- Formula
- C14H26O2
- EC
- 264-154-2
GRAS status: FEMA GRAS, publication 23. Recorded by FDA in the Substances Added to Food inventory under CAS 63449-64-9.
Structure
Identity
Also known as: 3-Hexene, 1,1′-[ethylidenebis(oxy)]bis-, (3Z,3′Z)-, 3-Hexene, 1,1′-[ethylidenebis(oxy)]bis-, (Z,Z)-, (3Z,3′Z)-1,1′-[Ethylidenebis(oxy)]bis[3-hexene], 3-hexene, 1,1'-[ethylidenebis(oxy)]bis-, (3z,3'z)-, 3-hexene, 1,1'-(ethylidenebis(oxy))bis-, (3z,3'z)-.
Can Acetaldehyde di-cis-3-hexenyl acetal be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
Acetaldehyde di-cis-3-hexenyl acetal is FEMA GRAS under FEMA number 4381. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Acetaldehyde di-cis-3-hexenyl acetal. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 1747, evaluated at the 64th meeting in 2005. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list. Listed on the EPA TSCA inventory.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Acetaldehyde di-cis-3-hexenyl acetal appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 63449-64-9, where EPA names it 3-Hexene, 1,1'-[ethylidenebis(oxy)]bis-, (3Z,3'Z)-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, green, fresh, floral.
Where it is used
Acetaldehyde di-cis-3-hexenyl acetal is used in beverage, confection, fruit flavors, bakery and dairy, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Acetaldehyde di-cis-3-hexenyl acetal by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Tributyrin | 2223 | 74% | In nature |
| Acetaldehyde diisoamyl acetal | 4024 | 71% | Not determined |
| Digeranyl ether | 4664 | 71% | Not determined |
| 6-Undecanone | 4022 | 70% | In nature |
More acetals in this index
Acetaldehyde butyl phenethyl acetal · Acetaldehyde 1,3-octadiol acetal · Acetaldehyde diisoamyl acetal · Hexanal butane-2,3-diol acetal · Hydroxycitronellal diethyl acetal · Vanillin 3-(l-menthoxy)propane-1,2-diol acetal
Acetaldehyde di-cis-3-hexenyl acetal FAQ
Does acetaldehyde di-cis-3-hexenyl acetal have FEMA GRAS status?
Acetaldehyde di-cis-3-hexenyl acetal holds FEMA GRAS status under FEMA number 4381. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite acetaldehyde di-cis-3-hexenyl acetal by FEMA or CAS number?
Cite acetaldehyde di-cis-3-hexenyl acetal as FEMA 4381 or CAS 63449-64-9; both point to the same entry. Its flavor category is fruity.
What does acetaldehyde di-cis-3-hexenyl acetal smell and taste like, and where is it used?
The odor of acetaldehyde di-cis-3-hexenyl acetal is sweet, fruity, green, fresh, floral. Typical uses are beverage, confection, fruit flavors, bakery and dairy.
What did JECFA conclude about acetaldehyde di-cis-3-hexenyl acetal?
JECFA evaluated acetaldehyde di-cis-3-hexenyl acetal at the 64th meeting in 2005 under JECFA number 1747. The panel concluded: no safety concern at current levels of intake.
Is acetaldehyde di-cis-3-hexenyl acetal approved in the EU?
No EU FL number is on file for acetaldehyde di-cis-3-hexenyl acetal. It has a JECFA evaluation (JECFA 1747), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ACETALDEHYDE DI-CIS-3-HEXENYL ACETAL under CAS 63449-64-9 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.