Flavor ingredient regulatory record
cis-3-Hexenyl anthranilate
cis-3-Hexenyl anthranilate is an ester in the fruity family, FEMA GRAS under FEMA number 3925 (CAS 65405-76-7). Its odor is sweet, fruity, green, floral.
- FEMA
- 3925
- CAS
- 65405-76-7
- JECFA
- 1538
- EU FL
- 09.561
- Formula
- C13H17NO2
- EC
- 265-744-2
GRAS status: FEMA GRAS, publication 19. Recorded by FDA in the Substances Added to Food inventory under CAS 65405-76-7.
Structure
Identity
Also known as: 3-Hexen-1-ol, 1-(2-aminobenzoate), (3Z)-, 3-Hexen-1-ol, 2-aminobenzoate, (Z)-, 3-Hexen-1-ol, 2-aminobenzoate, (3Z)-, (z)-hex-3-enyl anthranilate, 3-hexen-1-yl 2-aminobenzoate, 3-hexen-1-ol, 2-aminobenzoate, (z)-, (z)-3-hexenyl anthranilate, 3-hexenyl anthranilate, (3z)-, 3-hexen-1-ol, 2-aminobenzoate, (3z)-, 3-hexen-ol, 2-aminobenzoate, (z)-, 3-hexen-1-ol, 1-(2-aminobenzoate), (3z)-, 3-hexenyl anthranilate, cis-.
Can cis-3-Hexenyl anthranilate be labeled natural?
Nature makes cis-3-Hexenyl anthranilate, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial cis-3-Hexenyl anthranilate, same molecule. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
cis-3-Hexenyl anthranilate is FEMA GRAS under FEMA number 3925. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 09.561, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1538, evaluated at the 69th meeting in 2008. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. cis-3-Hexenyl anthranilate appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 65405-76-7, where EPA names it 3-Hexen-1-ol, 1-(2-aminobenzoate), (3Z)-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, green, floral.
Where it is used
cis-3-Hexenyl anthranilate is used in beverage, confection, fruit flavors and flavoring agents, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to cis-3-Hexenyl anthranilate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Butyl anthranilate | 2181 | 89% | In nature |
| Citronellyl anthranilate | 4086 | 77% | In nature |
| (Z)-Hex-3-enyl salicylate | 4750 | 76% | In nature |
| Linalyl anthranilate | 2637 | 75% | In nature |
| Ethyl anthranilate | 2421 | 71% | In nature |
More esters in this index
Bornyl acetate · Butyl salicylate · Menthyl isovalerate · Isoamyl isovalerate · Propyl 2,4-decadienoate · Ethyl 3-octenoate
cis-3-Hexenyl anthranilate FAQ
Does cis-3-Hexenyl anthranilate have FEMA GRAS status?
cis-3-Hexenyl anthranilate holds FEMA GRAS status under FEMA number 3925. The Code of Federal Regulations lists it at 21 CFR 172.515.
How do I cite cis-3-Hexenyl anthranilate by FEMA or CAS number?
Cite cis-3-Hexenyl anthranilate as FEMA 3925 or CAS 65405-76-7; both point to the same entry. Its flavor category is fruity.
What does cis-3-Hexenyl anthranilate smell and taste like, and where is it used?
The odor of cis-3-Hexenyl anthranilate is sweet, fruity, green, floral. Typical uses are beverage, confection, fruit flavors and flavoring agents.
What did JECFA conclude about cis-3-Hexenyl anthranilate?
JECFA evaluated cis-3-Hexenyl anthranilate at the 69th meeting in 2008 under JECFA number 1538. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Can cis-3-Hexenyl anthranilate be used in the EU and UK?
Yes. FL 09.561 is the Union List entry for cis-3-Hexenyl anthranilate, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Can cis-3-Hexenyl anthranilate be labeled a natural flavor?
The process decides for cis-3-Hexenyl anthranilate. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic cis-3-Hexenyl anthranilate is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as (Z)-3-HEXENYL ANTHRANILATE under CAS 65405-76-7 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.