Flavor ingredient regulatory record
Isoamyl isovalerate
Isoamyl isovalerate is an ester in the fruity family, FEMA GRAS under FEMA number 2085 (CAS 659-70-1). Its odor is sweet, fruity, banana, pear, apple.
- FEMA
- 2085
- CAS
- 659-70-1
- JECFA
- 50
- EU FL
- 09.463
- Formula
- C10H20O2
- EC
- 211-536-1
GRAS status: FEMA GRAS, publication 3. Recorded by FDA in the Substances Added to Food inventory under CAS 659-70-1.
Structure
Identity
Also known as: Butanoic acid, 3-methyl-, 3-methylbutyl ester, Isovaleric acid, isopentyl ester, Isopentyl alcohol, isovalerate, iso-Amyl isovalerate, Isopentyl isovalerate, 3-Methylbutyl 3-methylbutyrate, Isopentyl 3-methylbutyrate, Solusterol, Isopentyl 3-methylbutanoate, 3-Methylbutyl 3-methylbutanoate, 3-Methylbutyl isovalerate, Isoamyl 3-methylbutyrate.
Can Isoamyl isovalerate be labeled natural?
Nature makes isoamyl isovalerate, which is why the US label turns on process. A natural route gives natural flavor; synthesis gives artificial isoamyl isovalerate, same molecule. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic isoamyl isovalerate identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Isoamyl isovalerate is FEMA GRAS under FEMA number 2085. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 09.463, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (JECFA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 50, evaluated at the 46th meeting in 1996. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Isoamyl isovalerate appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 659-70-1, where EPA names it Butanoic acid, 3-methyl-, 3-methylbutyl ester.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, banana, pear, apple.
Where it is used
Isoamyl isovalerate is used in beverage, confection, fruit flavors, ice cream and bakery, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Isoamyl isovalerate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Butyl isovalerate | 2218 | 95% | In nature |
| Isoamyl 2-methylbutyrate | 3505 | 87% | In nature |
| Isoamyl acetoacetate | 3551 | 79% | In nature |
| Isoamyl hexanoate | 2075 | 78% | In nature |
| Isoamyl propionate | 2082 | 63% | In nature |
More esters in this index
n-Amyl heptanoate · Heptyl heptanoate · Ethyl 4-(acetylthio)butyrate · Butyl stearate · (E,Z)-3,6-Nonadien-1-ol acetate · Sodium 2-(4-methoxyphenoxy)propanoate
Isoamyl isovalerate FAQ
Is isoamyl isovalerate FEMA GRAS?
Yes. The FEMA Expert Panel lists isoamyl isovalerate as GRAS under FEMA number 2085. The Code of Federal Regulations lists it at 21 CFR 172.515.
What are the FEMA and CAS numbers for isoamyl isovalerate?
Isoamyl isovalerate is FEMA 2085, CAS 659-70-1. Its flavor category is fruity.
How is isoamyl isovalerate described, and where does it show up?
Flavorists describe isoamyl isovalerate as sweet, fruity, banana, pear, apple. It is used in beverage, confection, fruit flavors, ice cream and bakery.
What did JECFA conclude about isoamyl isovalerate?
JECFA evaluated isoamyl isovalerate at the 46th meeting in 1996 under JECFA number 50. The panel concluded: No safety concern at current levels of intake when used as a flavouring agent.
Is isoamyl isovalerate on the EU Union List?
Yes. FL 09.463 is the Union List entry for isoamyl isovalerate, annex I Part A, under Regulation 1334/2008, and the UK keeps the same list.
Does isoamyl isovalerate count as natural in the US and the EU?
The process decides for isoamyl isovalerate. It occurs in nature, so a natural-source, natural-process material is natural flavor in the US and synthetic isoamyl isovalerate is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic isoamyl isovalerate identical-to-natural.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ISOAMYL ISOVALERATE under CAS 659-70-1 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.