Flavor ingredient regulatory record
Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine
Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine is a natural complex flavoring material in the earthy family, FEMA GRAS under FEMA number 4100 (CAS 38888-81-2). Its odor is nutty, roasted, earthy, green, bell pepper.
- FEMA
- 4100
- CAS
- 38888-81-2
- JECFA
- 2130
GRAS status: FEMA GRAS, publication 22. Recorded by FDA in the Substances Added to Food inventory under CAS 70303-42-3.
Structure
Material
Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine is a natural complex material rather than a single molecule, so it has no one structure. FEMA lists it as Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine.
Identity
Can Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine is FEMA GRAS under FEMA number 4100. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
JECFA number 2130, evaluated at the 76th meeting in 2012. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Nutty, roasted, earthy, green, bell pepper.
Where it is used
Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine is used in savory snacks, seasonings, meat products and sauces, typically as a earthy note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 2-Isobutyl-3-methoxypyrazine | 3132 | 86% | In nature |
| 3-Isobutylpyridine | 3371 | 65% | In nature |
| 2-Isopropyl-3-methoxypyrazine | 3358 | 60% | In nature |
| 2-Isobutyl-4,5-dimethyloxazole | 4397 | 58% | In nature |
| 2,5-Diethyl-3-methylpyrazine | 3915 | 58% | In nature |
More pyrazines in this index
Methoxypyrazine · 2,3-Dimethylpyrazine · 1-Pyrroline · 2-Methoxy-3-(1-methylpropyl)pyrazine · 2-Acetyl-3-ethylpyrazine · 2-Ethoxy-3-methylpyrazine
Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine FAQ
Is Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine on the FEMA GRAS list?
It is. FEMA number 4100 covers Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine. It is also codified at 21 CFR 172.515.
What is the FEMA number for Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine?
The FEMA number for Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine is 4100 and its CAS registry number is 38888-81-2. FEMA files it in the earthy flavor category.
Is Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine approved in the EU?
No EU FL number is on file for Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine. It has a JECFA evaluation (JECFA 2130), which the EU list draws on, but the Union List entry itself should be confirmed before EU use.
Has JECFA evaluated Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine?
Yes. JECFA number 2130, evaluated at the 76th meeting in 2012. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
What is Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine used for?
Mixture of 3,5 and 3,6-Dimethyl-2-isobutylpyrazine is described as nutty, roasted, earthy, green, bell pepper. It shows up in savory snacks, seasonings, meat products and sauces.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 3,5-DIMETHYL-2-ISOBUTYLPYRAZINE under CAS 70303-42-3 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.