Flavor ingredient regulatory record
Piperonal propyleneglycol acetal
Piperonal propyleneglycol acetal is an aldehyde in the floral family, FEMA GRAS under FEMA number 4622 (CAS 61683-99-6). Its odor is sweet, floral, jasmine, citrus, earthy.
- FEMA
- 4622
- CAS
- 61683-99-6
- Formula
- C11H12O4
GRAS status: FEMA GRAS, publication 24. Recorded by FDA in the Substances Added to Food inventory under CAS 61683-99-6.
Structure
Identity
Also known as: 1,3-Benzodioxole, 5-(4-methyl-1,3-dioxolan-2-yl)-, 1,3-Dioxolane, 4-methyl-2-(3,4-methylenedioxyphenyl)-, 5-(4-Methyl-1,3-dioxolan-2-yl)-1,3-benzodioxole, NSC 406081, Piperonal propylene glycol acetal, 5-(4-methyl-1,3-dioxolan-2-yl)-1,3-benzodioxole, 1,3-benzodioxole, 5-(4-methyl-1,3-dioxolan-2-yl)-, piperonal propylene glycol acetal, heliotropyl propylene glycol acetal, ai3-20182, 1,3-benzodioxole, 5-(4-methyl-1,3-dioxolan-2-yl), 1,3-dioxolane, 4-methyl-2-(3,4-methylenedioxyphenyl)-.
Can Piperonal propyleneglycol acetal be labeled natural?
Nature occurrence: Not yet found in nature (provisional).
Nature occurrence has not been settled for this substance, so the natural or artificial class is not stated here. The FEMA GRAS status does not depend on it.
Regulatory status, with citations
United States
Piperonal propyleneglycol acetal is FEMA GRAS under FEMA number 4622. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
No EU FL number is on file for Piperonal propyleneglycol acetal. That is not a finding either way. The Union List covers defined flavouring substances, so natural complex materials are handled as flavouring preparations under Parts B to F and never receive a number, and substances used as additives sit under Regulation 1333/2008 instead. Confirm the position before EU or UK use.
JECFA (WHO / FAO)
Piperonal propyleneglycol acetal has not been evaluated by JECFA as a flavouring agent, or no evaluation is on file.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Piperonal propyleneglycol acetal appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 61683-99-6, where EPA names it 1,3-Benzodioxole, 5-(4-methyl-1,3-dioxolan-2-yl)-.
Inactive in US commerce
EPA designates this substance inactive, so a Notice of Activity Form B is required before anyone manufactures or processes it again. Being FEMA GRAS does not change that. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, floral, jasmine, citrus, earthy.
Where it is used
Piperonal propyleneglycol acetal is used in fragrance, beverage, confection and baked goods, typically as a floral note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Piperonal propyleneglycol acetal by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Vanillin propylene glycol acetal | 3905 | 80% | In nature |
| Anisaldehyde propyleneglycol acetal | 4627 | 76% | Not determined |
| Vanillin erythro- & threo-butan-2,3-diol acetal | 4023 | 75% | Not determined |
| Ethyl vanillin propylene glycol acetal | 3838 | 75% | In nature |
| 3-(3,4-Methylenedioxyphenyl)-2-methylpropanal | 4599 | 74% | Not determined |
More aldehydes in this index
Piperonal · 2-Hydroxy-4-methoxybenzaldehyde · o-Anisaldehyde · 4-Hydroxy-3,5-dimethoxybenzaldehyde · 4-Hydroxybenzaldehyde · Hydroxycitronellal
Piperonal propyleneglycol acetal FAQ
Is piperonal propyleneglycol acetal on the FEMA GRAS list?
It is. FEMA number 4622 covers piperonal propyleneglycol acetal. It is also codified at 21 CFR 172.515.
What is the FEMA number for piperonal propyleneglycol acetal?
The FEMA number for piperonal propyleneglycol acetal is 4622 and its CAS registry number is 61683-99-6. FEMA files it in the floral flavor category.
What is piperonal propyleneglycol acetal used for?
Piperonal propyleneglycol acetal is described as sweet, floral, jasmine, citrus, earthy. It shows up in fragrance, beverage, confection and baked goods.
Ingredient lookup
Check an ingredient
Start typing to search the ingredient corpus.
Or browse every ingredient page, A to Z.
Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
Check Piperonal propyleneglycol acetal in a formula
Screened against FEMA GRAS, 21 CFR and EU rules as you build. Free to start.
Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as PIPERONAL PROPYLENEGLYCOL ACETAL under CAS 61683-99-6 and carries its FEMA number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.