Flavor ingredient regulatory record
Ethyl N-methylanthranilate
Ethyl N-methylanthranilate is an ester in the fruity family, FEMA GRAS under FEMA number 4116 (CAS 35472-56-1). Its odor is sweet, fruity, grape, floral, candy.
- FEMA
- 4116
- CAS
- 35472-56-1
- JECFA
- 1546
- EU FL
- 09.765
- Formula
- C10H13NO2
GRAS status: FEMA GRAS, publication 22. Recorded by FDA in the Substances Added to Food inventory under CAS 35472-56-1.
Structure
Identity
Also known as: Benzoic acid, 2-(methylamino)-, ethyl ester, Anthranilic acid, N-methyl-, ethyl ester, Ethyl 2-(methylamino)benzoate, NSC 408328, ethyl 2-(methylamino)benzoate, benzoic acid, 2-(methylamino)-, ethyl ester, ethy n-methylanthranilate, ai3-05543, ethyl n-methylanthranilate [fhfi], anthranilic acid, n-methyl-, ethyl ester, ethyl 2-methylaminobenzoate, ethyl2-(methylamino)benzoate.
Can Ethyl N-methylanthranilate be labeled natural?
Ethyl N-methylanthranilate occurs in nature, so the label depends on the route: Ethyl N-methylanthranilate won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized Ethyl N-methylanthranilate is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Ethyl N-methylanthranilate is FEMA GRAS under FEMA number 4116. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 09.765, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1546, evaluated at the 69th meeting in 2008. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
Odor and taste
Odor: Sweet, fruity, grape, floral, candy.
Taste: Sweet, fruity, grape.
Where it is used
Ethyl N-methylanthranilate is used in beverage, confection, flavoring, desserts and candies, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Ethyl N-methylanthranilate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| Methyl N-methylanthranilate | 2718 | 85% | In nature |
| Isobutyl N-methylanthranilate | 4149 | 73% | In nature |
| N-Benzoylanthranilic acid | 4078 | 58% | In nature |
| Butyl salicylate | 3650 | 54% | In nature |
| N1-(2,4-Dimethoxybenzyl)-N2-(2-(pyridin-2-yl)ethyl)oxalamide | 4233 | 52% | Not determined |
More esters in this index
Furfuryl formate · Methyl (E)-2-(Z)-4-decadienoate · Ethyl 2-acetyloctanoate · Rum ether · alpha-Terpinyl acetate · 6-[5(6)-Decenoyloxy]decanoic acid
Ethyl N-methylanthranilate FAQ
Is Ethyl N-methylanthranilate FEMA GRAS?
Yes. The FEMA Expert Panel lists Ethyl N-methylanthranilate as GRAS under FEMA number 4116. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for Ethyl N-methylanthranilate?
Ethyl N-methylanthranilate is FEMA 4116, CAS 35472-56-1. FEMA files it in the fruity flavor category.
Does Ethyl N-methylanthranilate count as natural in the US and the EU?
Since Ethyl N-methylanthranilate is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when Ethyl N-methylanthranilate is synthesized. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
Is Ethyl N-methylanthranilate on the EU Union List?
Ethyl N-methylanthranilate is on the EU Union List of flavouring substances as FL 09.765 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated Ethyl N-methylanthranilate?
Yes. JECFA number 1546, evaluated at the 69th meeting in 2008. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
How is Ethyl N-methylanthranilate described, and where does it show up?
Flavorists describe Ethyl N-methylanthranilate as sweet, fruity, grape, floral, candy. On the palate it is sweet, fruity, grape. It is used in beverage, confection, flavoring, desserts and candies.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ETHYL N-METHYLANTHRANILATE under CAS 35472-56-1 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.