Flavor ingredient regulatory record
Heptan-2-ol
Heptan-2-ol is an alcohol in the fruity family, FEMA GRAS under FEMA number 3288 (CAS 543-49-7). Its odor is sweet, fruity, apple, floral, slightly fatty.
- FEMA
- 3288
- CAS
- 543-49-7
- JECFA
- 284
- EU FL
- 02.045
- Formula
- C7H16O
- EC
- 208-844-3
GRAS status: FEMA GRAS, publication 5. Recorded by FDA in the Substances Added to Food inventory under CAS 543-49-7.
Structure
Identity
Also known as: 2-Heptanol, Amyl methyl carbinol, s-Heptyl alcohol, 2-Hydroxyheptane, Methyl amyl carbinol, 2-Heptyl alcohol, 1-Methylhexanol, (±)-2-Heptanol, DL-Heptan-2-ol, NSC 2220, 1-Methyl-1-hexanol, 2-heptanol.
Can Heptan-2-ol be labeled natural?
Heptan-2-ol occurs in nature, so the label depends on the route: heptan-2-ol won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized heptan-2-ol is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Heptan-2-ol is FEMA GRAS under FEMA number 3288. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 02.045, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (JECFA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 284, evaluated at the 51st meeting in 1998. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Heptan-2-ol appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 543-49-7, where EPA names it 2-Heptanol.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, apple, floral, slightly fatty.
Where it is used
Heptan-2-ol is used in beverage, confection, fruit flavors, bakery and dairy, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Heptan-2-ol by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| 3-Heptanol | 3547 | 95% | In nature |
| Hexyl alcohol | 2567 | 94% | In nature |
| 2-Ethyl-1-hexanol | 3151 | 93% | In nature |
| 2-Heptanone | 2544 | 92% | In nature |
| 3-Octanol | 3581 | 88% | In nature |
More alcohols in this index
2-Nonanol · alpha,alpha-Dimethylphenethyl alcohol · alpha-Methylbenzyl alcohol · 1-Phenyl-1-propanol · (E,Z)-3,6-Nonadien-1-ol · (+/-)-2-Methyl-1-butanol
Heptan-2-ol FAQ
Is heptan-2-ol FEMA GRAS?
Yes. The FEMA Expert Panel lists heptan-2-ol as GRAS under FEMA number 3288. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for heptan-2-ol?
Heptan-2-ol is FEMA 3288, CAS 543-49-7. FEMA files it in the fruity flavor category.
Does heptan-2-ol count as natural in the US and the EU?
Since heptan-2-ol is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when heptan-2-ol is synthesized. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
Is heptan-2-ol on the EU Union List?
Heptan-2-ol is on the EU Union List of flavouring substances as FL 02.045 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated heptan-2-ol?
Yes. JECFA number 284, evaluated at the 51st meeting in 1998. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
How is heptan-2-ol described, and where does it show up?
Flavorists describe heptan-2-ol as sweet, fruity, apple, floral, slightly fatty. It is used in beverage, confection, fruit flavors, bakery and dairy.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as 2-HEPTANOL under CAS 543-49-7 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.