Flavor ingredient regulatory record
Isobornyl acetate
Isobornyl acetate is an ester in the fruity family, FEMA GRAS under FEMA number 2160 (CAS 125-12-2). Its odor is sweet, woody, floral, fruity, balsamic.
- FEMA
- 2160
- CAS
- 125-12-2
- JECFA
- 1388
- EU FL
- 09.218
- Formula
- C12H20O2
- EC
- 204-727-6
GRAS status: FEMA GRAS, publication 3. Recorded by FDA in the Substances Added to Food inventory under CAS 125-12-2.
Structure
Identity
Also known as: Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, 2-acetate, (1R,2R,4R)-rel-, Isoborneol, acetate, Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, acetate, exo-, Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, acetate, (1R,2R,4R)-rel-, Pichtosine, Pichtosin, (±)-Isobornyl acetate, exo-Bornyl acetate, NSC 62486, pichtosin, 2-bornyl acetate, exo-, 2-camphanyl acetate, exo-.
Can Isobornyl acetate be labeled natural?
Isobornyl acetate occurs in nature, so the label depends on the route: isobornyl acetate won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized isobornyl acetate is artificial. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
Isobornyl acetate is FEMA GRAS under FEMA number 2160. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 09.218, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (EFSA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 1388, evaluated at the 63rd meeting in 2004. no safety concern at current levels of intake.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. Isobornyl acetate appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 125-12-2, where EPA names it Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, 2-acetate, (1R,2R,4R)-rel-.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA publishes no regulatory flags on this listing. What the flags mean.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, woody, floral, fruity, balsamic.
Where it is used
Isobornyl acetate is used in beverage, confection, flavoring, perfume and cosmetics, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to Isobornyl acetate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| l-Bornyl acetate | 4080 | 100% | In nature |
| Bornyl acetate | 2159 | 100% | In nature |
| Bornyl formate | 2161 | 92% | In nature |
| Bornyl isovalerate | 2165 | 90% | In nature |
| Bornyl butyrate | 3907 | 88% | In nature |
More esters in this index
Citric acid ester of mono-and di-glycerides of fatty acids · Trilobatin · Bornyl acetate · Isobutyl cinnamate · 2-Ethanethoic acid, S-(2-methyl-3-furanyl) ester · Butyl isobutyrate
Isobornyl acetate FAQ
Is isobornyl acetate FEMA GRAS?
Yes. The FEMA Expert Panel lists isobornyl acetate as GRAS under FEMA number 2160. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for isobornyl acetate?
Isobornyl acetate is FEMA 2160, CAS 125-12-2. FEMA files it in the fruity flavor category.
Does isobornyl acetate count as natural in the US and the EU?
Since isobornyl acetate is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when isobornyl acetate is synthesized. The EU and UK grant the natural claim only to that natural route; Mercosur and Mexico call synthetic material identical-to-natural.
Is isobornyl acetate on the EU Union List?
Isobornyl acetate is on the EU Union List of flavouring substances as FL 09.218 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated isobornyl acetate?
Yes. JECFA number 1388, evaluated at the 63rd meeting in 2004. Conclusion: no safety concern at current levels of intake.
How is isobornyl acetate described, and where does it show up?
Flavorists describe isobornyl acetate as sweet, woody, floral, fruity, balsamic. It is used in beverage, confection, flavoring, perfume and cosmetics.
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Guides: What Is FEMA GRAS? · Natural vs artificial · Filing a GRAS notification
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as ISOBORNYL ACETATE under CAS 125-12-2 and carries its FEMA number, its JECFA flavor number and its 21 CFR citations. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.