Flavor ingredient regulatory record
mono-Menthyl succinate
mono-Menthyl succinate is an ester in the fruity family, FEMA GRAS under FEMA number 3810 (CAS 77341-67-4). Its odor is sweet, fruity, floral, peach, berry.
- FEMA
- 3810
- CAS
- 77341-67-4
- JECFA
- 447
- EU FL
- 09.616
- Formula
- C14H24O4
- EC
- 426-890-4
GRAS status: FEMA GRAS, publication 17. Recorded by FDA in the Substances Added to Food inventory under CAS 77341-67-4.
Structure
Identity
Also known as: Butanedioic acid, 1-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester, Butanedioic acid, mono[5-methyl-2-(1-methylethyl)cyclohexyl] ester, [1R-(1α,2β,5α)]-, Butanedioic acid, mono[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester, 1-[(1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl] butanedioate, Physcool, Succinic acid menthol monoester, Physcool N 2188, FEMA 3810, Fema Gras 3810, Monomenthyl succinate, physcool, monomenthyl succinate, (-)-.
Can mono-Menthyl succinate be labeled natural?
Since mono-Menthyl succinate is found in nature, US labeling follows how it was obtained: natural flavor from a natural source and a natural process, artificial when mono-Menthyl succinate is synthesized. In the EU and UK the natural claim likewise needs the natural route, while Mercosur and Mexico keep a third class, identical-to-natural, for the synthetic material.
- United States
- Natural or artificial, by process
- European Union and UK
- Natural only from natural material
- Mercosur and Mexico
- Natural or identical-to-natural
How each market defines the classes: natural vs artificial flavor under 21 CFR 101.22.
Regulatory status, with citations
United States
mono-Menthyl succinate is FEMA GRAS under FEMA number 3810. It is cited in the Code of Federal Regulations at 21 CFR 172.515.
European Union and United Kingdom
Listed on the Union List of flavouring substances as FL 09.616, Annex I Part A under Regulation (EC) 1334/2008, evaluation status approved (JECFA). The UK retains the same list.
JECFA (WHO / FAO)
JECFA number 447, evaluated at the 51st meeting in 1998. No safety concern at current levels of intake when used as a flavouring agent.
Other US flags
Not on the California Proposition 65 list.
TSCA Inventory status
A flavor ingredient is also an industrial chemical. mono-Menthyl succinate appears on the EPA Toxic Substances Control Act Chemical Substance Inventory under CAS 77341-67-4, where EPA names it Butanedioic acid, 1-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester.
Active in US commerce
EPA designates this substance active, so no Notice of Activity Form B is required before manufacturing. What active and inactive mean.
EPA regulatory flags
| Flag | EPA definition | What it obliges |
|---|---|---|
| PMN | Indicates a commenced PMN substance. | Nothing new. The substance already went through premanufacture review and someone filed a notice of commencement, which is why it is on the Inventory. It is an existing chemical and needs no new premanufacture notice. Read more |
PMN does not establish: The flag records how the substance arrived, not what may be done with it. Check the flags beside it.
From the EPA non-confidential TSCA Inventory, July 2026 release. EPA also maintains a confidential portion it does not publish. Search the Inventory by CAS number.
Odor and taste
Odor: Sweet, fruity, floral, peach, berry.
Where it is used
mono-Menthyl succinate is used in beverage, confection, fruit flavors, bakery and desserts, typically as a fruity note.
Structurally similar flavor ingredients
Flavor ingredients with a GRAS determination closest to mono-Menthyl succinate by structure. Whether one can replace it is a sensory and regulatory call; the reformulation tool works that through.
| Material | FEMA | Similarity | Occurrence |
|---|---|---|---|
| (+/-) N,N-Dimethyl menthyl succinamide | 4230 | 74% | Not determined |
| Menthyl valerate | 4156 | 74% | In nature |
| N-[(Ethoxycarbonyl)methyl)-p-menthane-3-carboxamide | 4309 | 69% | Not determined |
| D,L-Menthol(+/-)-propylene glycol carbonate | 3992 | 68% | In nature |
| Menthyl isovalerate | 2669 | 68% | In nature |
More esters in this index
Benzyl levulinate · cis-3-Hexenyl acetoacetate · Rhodinyl butyrate · Cyclohexyl cinnamate · 6-[5(6)-Decenoyloxy]decanoic acid · Ethyl N-methylanthranilate
mono-Menthyl succinate FAQ
Is mono-Menthyl succinate FEMA GRAS?
Yes. The FEMA Expert Panel lists mono-Menthyl succinate as GRAS under FEMA number 3810. It is also codified at 21 CFR 172.515.
What are the FEMA and CAS numbers for mono-Menthyl succinate?
mono-Menthyl succinate is FEMA 3810, CAS 77341-67-4. FEMA files it in the fruity flavor category.
Does mono-Menthyl succinate count as natural in the US and the EU?
mono-Menthyl succinate occurs in nature, so the label depends on the route: mono-Menthyl succinate won from a natural source by a physical, enzymatic or microbiological process is natural flavor in the United States, and synthesized mono-Menthyl succinate is artificial. The EU and UK follow the same logic without a middle class; Mercosur and Mexico label synthetic mono-Menthyl succinate identical-to-natural.
Is mono-Menthyl succinate on the EU Union List?
mono-Menthyl succinate is on the EU Union List of flavouring substances as FL 09.616 (Annex I Part A) under Regulation 1334/2008.
Has JECFA evaluated mono-Menthyl succinate?
Yes. JECFA number 447, evaluated at the 51st meeting in 1998. Conclusion: No safety concern at current levels of intake when used as a flavouring agent.
How is mono-Menthyl succinate described, and where does it show up?
Flavorists describe mono-Menthyl succinate as sweet, fruity, floral, peach, berry. It is used in beverage, confection, fruit flavors, bakery and desserts.
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Sources and attribution. The identity and regulatory facts on this page are taken from the FDA Substances Added to Food inventory, a US government record, which lists this substance as MONOMENTHYL SUCCINATE under CAS 77341-67-4 and carries its FEMA number, its JECFA flavor number. The inventory is searchable at FDA. FDA records its technical effect as flavoring agent or adjuvant.
A FEMA GRAS conclusion is reached by the Expert Panel of the Flavor and Extract Manufacturers Association of the United States, and the FEMA number names that conclusion. FEMA publishes its own entry for this substance in the FEMA Flavor Library, which is the authoritative record of what the Panel decided and is worth reading alongside this page.
Ambrose Compliance is not affiliated with, endorsed by, or sponsored by FEMA. FEMA and FEMA GRAS are used here as identifiers for a published regulatory determination, not as marks of any relationship between FEMA and Ambrose.
About this page. Facts come from the FDA Substances Added to Food inventory, the Code of Federal Regulations, the EPA TSCA Inventory, the EU Union List, JECFA and the Ambrose database, with FEMA's published determination cited where it applies; parts of the text are written by Ambrose AI, which can make mistakes. Check the cited source before relying on anything here. This is not regulatory or legal advice.